PMID: 9420213Jan 7, 1998Paper

The 131-amino-acid repeat region of the essential 39-kilodalton core protein of fowlpox virus FP9, equivalent to vaccinia virus A4L protein, is nonessential and highly immunogenic

Journal of Virology
Denise BoulangerM A Skinner

Abstract

The immunodominant, 39,000-molecular weight core protein (39K protein) of fowlpox virus (FP9 strain), equivalent to the vaccinia virus A4L gene product, contains highly charged domains at each end of the protein and multiple copies of a 12-amino-acid serine-rich repeat sequence in the middle of the protein. Similar repeats were also detected in other fowlpox virus strains, suggesting that they might confer a selective advantage to the virus. The molloscum contagiosum virus homolog (MC107L) also contains repeats, unlike the vaccinia virus protein. The number of repeats in the fowlpox virus protein does not seem to be crucial, since some strains have a different number of repeats, as shown by the difference in the size of the protein in these strains. The repeat region could be deleted, indicating that it is not essential for replication in vitro. It was not possible to delete the entire 39K protein, indicating that it was essential (transcriptional control signals for the flanking genes were left intact). The repeat region is partly responsible for the immunodominance of the protein, but the C-terminal part of the protein also contains highly antigenic linear epitopes. A role for the 39K protein in immune system modulation is di...Continue Reading

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Citations

Dec 13, 2003·Journal of Virology·G DelhonD L Rock
Oct 1, 2000·Avian Pathology : Journal of the W.V.P.A·P SinghD N Tripathy
Jun 14, 2003·Journal of Virology·Chris UptonRachel L Roper
Feb 13, 2003·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Pratik SinghDeoki N Tripathy
Sep 5, 2002·Journal of Virology·Denise BoulangerMichael A Skinner
Mar 26, 2002·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·G IsaC P Czerny
Feb 17, 2000·The Journal of General Virology·D BoulangerM A Skinner
Mar 11, 2005·Expert Review of Vaccines·Michael A SkinnerMatthew G Cottingham
Mar 23, 2000·Journal of Virology·C L AfonsoD L Rock
Apr 16, 2013·Avian Pathology : Journal of the W.V.P.A·R F SlocombeP Holz

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