PMID: 11929397Apr 4, 2002Paper

The 13C-urea breath test to detect Helicobacter pylori infection: a validated simple methodology with 50 mg 13C-urea

Alimentary Pharmacology & Therapeutics
C-C LiaoC-H Wu

Abstract

Several modifications of the 13C-urea breath test have been published. For reasons of cost efficiency and practicability, the urea dose and measurement duration should be reduced while still maintaining excellent diagnostic accuracy. To establish a validated simple protocol for the urea breath test with 50 mg 13C-urea and to compare this protocol with the conventional urea breath test with 100 mg 13C-urea. Conventional urea breath test with 100 mg 13C-urea was performed on 152 dyspeptic patients. Full-cream cow's milk was used as the test meal. Breath tests were repeated using 50 mg 13C-urea and the breath samples were collected at baseline and at 10 (protocol t10), 15 (protocol t15) and 30 min (protocol t30). Helicobacter pylori status was assessed by rapid urease test, histology and conventional urea breath test with 100 mg 13C-urea. With protocol t15, the best combination of sensitivity (99.1%), specificity (97.3%) and accuracy (98.7%) was obtained with a cut-off of 2.5 per thousand. There was an extremely high correlation coefficient between the three protocols and conventional 13C-urea breath test (all P < 0.001). A urea breath test with 50 mg 13C-urea using a simple test meal and a 15-min sampling interval with a low cut-...Continue Reading

References

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Feb 12, 1998·European Journal of Gastroenterology & Hepatology·V EllenriederG Adler
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Citations

Dec 1, 2004·Alimentary Pharmacology & Therapeutics·J P Gisbert, J M Pajares
Sep 24, 2005·Scandinavian Journal of Clinical and Laboratory Investigation·M KopácováV Palicka
Jun 29, 2011·Arquivos De Gastroenterologia·Luiz Gonzaga Vaz CoelhoElisa Viana Santa-Cecilia
Mar 16, 2018·The Cochrane Database of Systematic Reviews·Lawrence Mj BestKurinchi Selvan Gurusamy
Jan 9, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Wojciech FilipiakJakob Troppmair

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