The 14-3-3σ tumor suppressor has multiple functions in ErbB2-induced breast cancer

Cancer Discovery
Nancy E Hynes, Tatiana Smirnova

Abstract

Ling and colleagues demonstrated that loss of the conditional 14-3-3σ allele results in accelerated HER2/ERBB2-driven mammary tumorigenesis and metastasis. This study underscores the role of 14-3-3σ as a potent tumor suppressor in ERBB2-driven tumor initiation and progression.

References

Mar 1, 1991·Genes, Chromosomes & Cancer·G StenmanP Sahlin
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·A T FergusonS Sukumar
Jan 23, 2004·Nature Reviews. Cancer·Heiko Hermeking
Jul 17, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Paulette MhawechJuerg Schwaller
Jan 13, 2005·Molecular & Cellular Proteomics : MCP·José M A MoreiraJulio E Celis
May 9, 2006·Seminars in Cancer Biology·Alastair Aitken
May 5, 2010·Genes & Development·Chen LingWilliam J Muller
Nov 5, 2010·Cold Spring Harbor Perspectives in Biology·Charles M Perou, Anne-Lise Børresen-Dale
Sep 29, 2011·Seminars in Cell & Developmental Biology·Alexandra K Gardino, Michael B Yaffe
Nov 15, 2011·The Journal of Pathology·Kalnisha NaidooTatjana Crnogorac-Jurcevic

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