The 15-amino acid motif of the C terminus of the beta2-adrenergic receptor is sufficient to confer insulin-stimulated counterregulation to the beta1-adrenergic receptor

Endocrinology
Shai GaviC C Malbon

Abstract

Insulin counterregulates catecholamine action in part by inducing the sequestration of beta2-adrenergic receptors. Although similar to agonist-induced sequestration, insulin-induced internalization of beta2-adrenergic receptors operates through a distinct and better-understood cellular pathway. The effects of insulin treatment on the function and trafficking of both beta1- and beta2-adrenergic receptors were tested. The beta2-adrenergic receptors were counterregulated and internalized in response to insulin. The beta1-adrenergic receptors, in sharp contrast, are shown to be resistant to the ability of insulin to counterregulate function and induce receptor internalization. Using chimeric receptors composed of beta1-/beta2-adrenergic receptors in tandem with mutagenesis, we explored the role of the C-terminal cytoplasmic tail of the beta2-adrenergic receptors for insulin-induced counterregulation. Substitution of the C-terminal cytoplasmic tail of the beta2-adrenergic receptor on the beta1-adrenergic receptor enabled the chimeric G protein-coupled receptor to be functionally and spatially regulated by insulin. Truncation of the beta2-adrenergic receptor C-terminal cytoplasmic tail to a 15-amino acid motif harboring a potential S...Continue Reading

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Citations

Sep 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Rachel Vistein, Manojkumar A Puthenveedu
Oct 31, 2014·International Journal of Molecular Sciences·Fabio CattaneoRosario Ammendola
Sep 11, 2010·European Journal of Pharmacology·J Adolfo García-SáinzLuz del Carmen Medina
May 25, 2010·Experimental Eye Research·Youde JiangJena J Steinle
Jan 24, 2009·The International Journal of Health Planning and Management·Joseph F Naimoli
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Feb 8, 2006·Trends in Endocrinology and Metabolism : TEM·Shai GaviCraig C Malbon
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Mar 23, 2017·Journal of Cardiovascular Pharmacology·Qin FuYang K Xiang
Apr 11, 2008·Allergy·J MullolP Van Cauwenberge

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