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The 2-thiouridine unit in the RNA strand is desulfured predominantly to 4-pyrimidinone nucleoside under in vitro oxidative stress conditions

Chemical Communications : Chem Comm

Mar 25, 2011

Elzbieta SochackaBarbara Nawrot

Abstract

The 2-thiouridine (S2U) unit in the RNA strand is predominantly desulfured with H(2)O(2) to 4-pyrimidinone nucleoside (H2U). The resulting H2U-RNA exhibits significantly lower binding affinity to its complementary strand and in certain conditions undergoes strand scission. These results...read more

Mentioned in this Paper

Surface Enhanced Laser Desorption Ionization Mass Spectrometry
MT-TA gene
Sulfur
Triplet Codon-amino Acid Adaptor Activity
Oxidative Stress
Oxidative Stress Analysis
Transfer RNA
Pyrimidones
Freezing Point Temperature
Base Pairing
Paper Details
References
  • References13
  • Citations11
12
  • References13
  • Citations11
12

The 2-thiouridine unit in the RNA strand is desulfured predominantly to 4-pyrimidinone nucleoside under in vitro oxidative stress conditions

Chemical Communications : Chem Comm

Mar 25, 2011

Elzbieta SochackaBarbara Nawrot

PMID: 21431224

DOI: 10.1039/c1cc10973a

Abstract

The 2-thiouridine (S2U) unit in the RNA strand is predominantly desulfured with H(2)O(2) to 4-pyrimidinone nucleoside (H2U). The resulting H2U-RNA exhibits significantly lower binding affinity to its complementary strand and in certain conditions undergoes strand scission. These results...read more

Mentioned in this Paper

Surface Enhanced Laser Desorption Ionization Mass Spectrometry
MT-TA gene
Sulfur
Triplet Codon-amino Acid Adaptor Activity
Oxidative Stress
Oxidative Stress Analysis
Transfer RNA
Pyrimidones
Freezing Point Temperature
Base Pairing

Related Papers

Paper Details
References
  • References13
  • Citations11
12
  • References13
  • Citations11
12
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