The 2008 ESPEN Sir David Cuthbertson Lecture: Fatty acids and inflammation--from the membrane to the nucleus and from the laboratory bench to the clinic

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Philip C Calder

Abstract

Many chronic conditions involve excessive inflammation that is damaging to host tissues. Excessive or inappropriate inflammation and immunosuppression are components of the response to surgery, trauma, injury and infection in some individuals and these can lead, progressively, to sepsis and septic shock. Hyperinflammation is characterised by the production of inflammatory cytokines, eicosanoids and other inflammatory mediators, while the immunosuppression is characterised by impairment of antigen presentation and of certain T cell responses. N-6 fatty acids may contribute to the hyperinflamed and immunosuppressed states. N-3 fatty acids from fish oil decrease the production of inflammatory cytokines and eicosanoids. They act both directly (by replacing arachidonic acid as an eicosanoid precursor) and indirectly (by altering the expression of inflammatory genes through effects on transcription factor activation). Thus, these fatty acids are potentially useful anti-inflammatory agents and may be of benefit in patients with chronic inflammatory diseases or at risk of hyperinflammation and sepsis. An emerging application of n-3 fatty acids is in surgical or critically ill patients where they may be added to parenteral or enteral fo...Continue Reading

References

Jul 1, 1992·The Journal of Surgical Research·W ErtelI H Chaudry
Apr 1, 1991·The Journal of Experimental Medicine·H R AlexanderJ A Norton
Mar 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·M J MurrayT L Yaksh
Sep 1, 1991·Annals of Surgery·J T GrbicM L Rodrick
Feb 1, 1990·The British Journal of Surgery·M J HershmanH C Polk
Feb 1, 1989·The American Journal of Clinical Nutrition·E A MascioliG L Blackburn
Mar 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·J J PomposelliG L Blackburn
Aug 18, 1988·The New England Journal of Medicine·E GirardinP H Lambert
Nov 30, 1983·Biochemical and Biophysical Research Communications·D W GoldmanE J Goetzl
Jan 5, 1995·The New England Journal of Medicine·M H Kollef, D P Schuster
Jul 1, 1993·The Journal of Trauma·J A JohnsonF F Muakkassa
Feb 1, 1993·The Journal of Clinical Investigation·R I SperlingD R Robinson
Jun 1, 1996·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R AbbateG G Neri Serneri
Dec 13, 1996·Biochemical and Biophysical Research Communications·S CamandolaG Poli
Mar 27, 1998·Seminars in Thrombosis and Hemostasis·M G VervloetC E Hack
May 20, 1998·Metabolism: Clinical and Experimental·V M YoungB Hennig

❮ Previous
Next ❯

Citations

May 24, 2011·Current Gastroenterology Reports·Craig MunroeStephen A McClave
Jan 8, 2013·Appetite·Heather Francis, Richard Stevenson
Dec 25, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Karina V BarrosVera L Flor Silveira
Sep 24, 2010·The British Journal of Nutrition·Remko S KuipersFrits A J Muskiet
Mar 21, 2012·The Proceedings of the Nutrition Society·D Joe Millward
May 15, 2013·The Proceedings of the Nutrition Society·Philip C Calder
May 15, 2013·The Proceedings of the Nutrition Society·Philip C Calder
Nov 14, 2012·Critical Care : the Official Journal of the Critical Care Forum·Philip C Calder
Dec 24, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·John W C SijbenBerthold Koletzko
Apr 28, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Momoka OtsukaMichio Sata
Mar 26, 2016·Life Sciences·Bianca W P LoboGisela Maria Dellamora-Ortiz
Jun 21, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Nicolaas E P DeutzRobert R Wolfe
Jan 1, 2014·Mechanisms of Ageing and Development·Mònica MaijóSimon R Carding
Jan 27, 2011·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Krista L TurnerRobert Martindale
Mar 16, 2017·Nutrition Research Reviews·Marina Aparicio-SotoCatalina Alarcón-de-la-Lastra
Sep 9, 2011·JPEN. Journal of Parenteral and Enteral Nutrition·Robert G MartindaleLaszlo Kiraly
Mar 9, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Karina V BarrosVera L Flor Silveira
Jan 28, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Maria Fernanda Cury-BoaventuraDan Linetzky Waitzberg
Mar 10, 2016·Journal of Clinical Medicine·Stanislaw Klek
Jul 24, 2012·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Críspulo GallegosEdmundo Brito-de la Fuente
Apr 17, 2014·Critical Care Medicine·Philip C Calder
Aug 26, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Patricia Savino
Jul 7, 2012·British Journal of Clinical Pharmacology·Philip C Calder

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here