The 2018 correlative microscopy techniques roadmap.

Journal of Physics D: Applied Physics
Toshio AndoGiovanni Zifarelli

Abstract

Developments in microscopy have been instrumental to progress in the life sciences, and many new techniques have been introduced and led to new discoveries throughout the last century. A wide and diverse range of methodologies is now available, including electron microscopy, atomic force microscopy, magnetic resonance imaging, small-angle x-ray scattering and multiple super-resolution fluorescence techniques, and each of these methods provides valuable read-outs to meet the demands set by the samples under study. Yet, the investigation of cell development requires a multi-parametric approach to address both the structure and spatio-temporal organization of organelles, and also the transduction of chemical signals and forces involved in cell-cell interactions. Although the microscopy technologies for observing each of these characteristics are well developed, none of them can offer read-out of all characteristics simultaneously, which limits the information content of a measurement. For example, while electron microscopy is able to disclose the structural layout of cells and the macromolecular arrangement of proteins, it cannot directly follow dynamics in living cells. The latter can be achieved with fluorescence microscopy whic...Continue Reading

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Citations

Jun 9, 2019·Journal of Microscopy·Christian LaurentRoeland DE Kat
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Methods Mentioned

BETA
electron
scanning electron microscopy
electron microscopy
electron tomography
light
fluorescence microscopy
fluorescence imaging
x-ray imaging
correlative microscopy
light microscopy

Software Mentioned

Volume
AFM
MINFLUX
ColorEM
ESEM
STORM
TFM
FM
Delmic
HS

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