The 2039 A/G FSH receptor gene polymorphism influences glucose metabolism in healthy men.

Endocrine
Rossella CannarellaAldo E Calogero

Abstract

To assess the role of c. 2039 A/G (p. Asp680Ser) (rs6166) and c. -29 G/A (rs1394205) follicle-stimulating hormone receptor (FSHR) gene single nucleotide polymorphisms (SNPs) in a cohort of healthy men. One-hundred twenty-seven healthy men underwent evaluation of the anthropometric parameters, assessment of metabolic and lipid profile, measurement FSH serum levels, and genotyping of both the aforementioned FSHR SNPs. Data grouped according to the FSHR rs6166 or rs1394205 genotypes underwent to statistical analysis. The three groups of men for each FSHR SNP did not differ statistically significantly for body mass index and serum FSH levels. As for FSHR rs6166 SNP, glucose levels were significantly lower in men with the GG genotype compared with those with the AA genotype. Men with AG had lower insulin levels and HOMA index values compared with those carrying the genotype AA (p < 0.05). The GG group showed a negative correlation between serum FSH levels and insulin and between serum FSH levels and HOMA index (p < 0.05). In contrast, men grouped according to the FSHR rs1394205 genotype showed no significant difference in blood glucose, serum insulin levels, and HOMA index. The AG group showed a negative correlation between FSH insu...Continue Reading

References

Oct 3, 2002·Molecular Human Reproduction·Satoko SudoSeiichiro Fujimoto
Aug 30, 2005·Trends in Endocrinology and Metabolism : TEM·Jörg Gromoll, Manuela Simoni
Apr 25, 2006·Cell·Li SunMone Zaidi
Mar 26, 2010·European Journal of Endocrinology·Domenico RendinaLuigi Gennari
Jul 14, 2012·The Journal of Clinical Endocrinology and Metabolism·Frank TüttelmannJörg Gromoll
Nov 30, 2013·European Journal of Endocrinology·Manuela Simoni, Livio Casarini
Jun 1, 2014·Vascular Medicine·Vincenza BarresiDaniele Filippo Condorelli
Jun 28, 2014·Molecular and Cellular Endocrinology·Livio CasariniManuela Simoni
Oct 27, 2015·Calcified Tissue International·Antonino LascoAntonino Catalano
Dec 25, 2015·The Journal of Biological Chemistry·Nathan C Law, Mary E Hunzicker-Dunn
Apr 25, 2016·Journal of Diabetes and Its Complications·Vasilios PergialiotisDespina Perrea
Jun 19, 2017·Journal of Assisted Reproduction and Genetics·L TamburinoA E Calogero
Sep 14, 2017·Endocrine Connections·Rossella CannarellaAldo E Calogero
May 3, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Midori HonmaHideki Katagiri
Nov 27, 2018·The Journal of Clinical Endocrinology and Metabolism·Pei XuJian-Qiao Liu
May 1, 2019·Journal of Clinical Medicine·Rossella CannarellaAldo E Calogero
Jun 9, 2019·Journal of Clinical Medicine·Rossella CannarellaAldo E Calogero
Jun 9, 2019·Journal of Clinical Medicine·Rossella CannarellaAldo E Calogero
Jul 6, 2019·Asian Journal of Andrology·Rossella CannarellaAldo E Calogero

❮ Previous
Next ❯

Citations

Dec 5, 2020·International Journal of Endocrinology·Chen ZhangYongfeng Song

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhonghua nan ke xue = National journal of andrology
Qiuyue WuYu-feng Huang
Trends in Endocrinology and Metabolism : TEM
J Gromoll, M Simoni
© 2021 Meta ULC. All rights reserved