The 24-hour rhythm of oxytocin and beta-endorphin secretion in human pregnancy

Clinical Endocrinology
S W LindowZ M van der Spuy

Abstract

Animal work suggests that maternal oxytocin secretion is influenced by the secretion of endogenous opioids in pregnancy. Spontaneous labour and pre-labour uterine activity follow a 24-hour rhythm the origin of which has not been explained but may be related to diurnal changes in oxytocin secretion. This study was performed to document the changes over a 24-hour period in maternal oxytocin and beta-endorphin secretion. A 4-hourly blood profile was undertaken for a 24-hour period. Sixteen women with singleton pregnancies of more than 36 weeks gestation and 10 women with pregnancies in the mid trimester were studied. Blood was sampled 4-hourly for 24 hours beginning at 1200 h. Oxytocin was measured in all patients and beta-endorphin-like immunoreactivity was measured in 15 patients. A simple index was defined for comparing night-time levels to daytime levels for both oxytocin and beta-endorphin. In all cases more than 36 weeks gestation the index was positive for oxytocin (night-time levels were higher) and in all cases the index was negative for beta-endorphin (night-time levels were lower). In the mid trimester women all values of the index for oxytocin were positive but in the beta-endorphin group equal numbers demonstrated a p...Continue Reading

Citations

Sep 25, 2007·Die Naturwissenschaften·Alexander Lerchl, Sarah C Reinhard
Jul 24, 2010·Archives of Gynecology and Obstetrics·Ioannis KalogiannidisTheodoros Agorastos
Jan 30, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·S Ngwenya, S W Lindow
Sep 26, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·S W LindowJ W Thompson
Dec 3, 2014·Annals of Epidemiology·Miguel Angel Luque-FernandezMichelle A Williams
Mar 3, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·J J BakkerJ A Van Der Post
Jul 25, 2012·Annals of the New York Academy of Sciences·Beatriz Gómez-GonzálezJavier Velázquez-Moctezuma
Nov 26, 2013·Acta Obstetricia Et Gynecologica Scandinavica·Mark P HehirRhona Mahony
May 27, 2008·American Journal of Obstetrics and Gynecology·Aaron B CaugheyRussell K Laros
Jan 7, 2010·Journal of Affective Disorders·Ilona S YimCurt A Sandman
Sep 29, 2009·Revista brasileira de anestesiologia·Nilton Bezerra do ValeJosé Rômulo Cruz
Nov 10, 2009·Anesthesia and Analgesia·Barbara M ScavoneJohn T Sullivan
Oct 10, 2014·Journal of Perinatal Medicine·Sandeep KanwarStephen W Lindow
Jun 22, 2010·Chronobiology International·Waleska Schneider VieiraWolnei Caumo
Sep 8, 2018·Archives of Women's Mental Health·Sandraluz Lara-CinisomoCort A Pedersen
Jul 13, 2014·Fertility and Sterility·James Olcese, Stephen Beesley
Jul 13, 2004·British Journal of Anaesthesia·A G M AyaJ E de La Coussaye

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