The 262T>C promoter polymorphism of the catalase gene is associated with diabetic neuropathy in type 1 diabetic Russian patients

Diabetes & Metabolism
D A ChistiakovV V Nosikov

Abstract

Oxidative stress plays an important role in the development of diabetic neuropathy (DN). Antioxidant enzymes reduce enhanced oxidative stress in the peripheral nerve. Genetic variations within the antioxidant genes therefore could be implicated in the pathogenesis of DN. Using a PCR-RFLP assay, a total of 216 Russian type 1 diabetic (T1D) patients with DN and 250 T1D individuals without DN have been tested to verify whether the -262T > C and 1167C > T polymorphisms of the catalase (CAT), 197Pro > Leu amino acid substitution of the glutathione peroxidase 1 (GPX1) and +/null polymorphism of the glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) genes contribute to susceptibility to DN. Association between the -262T > C polymorphism of the CAT gene and DN was shown. The -262TT genotype of the CAT gene was significantly associated with higher erythrocyte catalase activity in blood of DN patients compared to the -262CC genotype (17.8 +/- 2.7 x 104 IU/g Hb vs. 13.5 +/- 3.2 x 104 IU/g Hb, P = 0.0022). These data suggest a protective role of the -262T allele of the CAT gene against the rapid development of DN in T1D (Odds Ratio = 0.7 [95% confidence interval 0.54-0.9], P = 0.002).

References

Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J SeidegårdW R Pearson
Jan 22, 1998·Free Radical Biology & Medicine·P S van DamJ J Marx
Aug 31, 2002·Diabetes/metabolism Research and Reviews·P J DickinsonA J M Boulton
Dec 28, 2002·Diabetes Care·UNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Nov 13, 2003·Current Diabetes Reports·Irina G Obrosova

❮ Previous
Next ❯

Citations

Nov 29, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ertugrul UzarNebahat Tasdemir
Feb 18, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Amanda CrawfordDominic P Geraghty
Jul 25, 2014·BioMed Research International·A Lourdhu MaryT Angeline
Feb 22, 2013·Journal of Gastroenterology and Hepatology·Siamak KhodayariSaeideh Torabi Dalivandan
Feb 23, 2011·Archives of Physiology and Biochemistry·Lukáš PácalKateřina Kaňková
Jun 16, 2015·Frontiers in Endocrinology·Ini-Isabée WitzelHabiba Alsafar
Sep 7, 2016·Diabetes Research and Clinical Practice·Cristina PolitiVincenza Spallone
Feb 23, 2013·Obesity Facts·Lucie VávrováAleš Zák
Sep 5, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pierre NahonMichel Beaugrand
May 24, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Marylise Hebert-SchusterValérie Nivet-Antoine
May 15, 2019·Diabetes/metabolism Research and Reviews·Dimitra KallinikouKyriaki Karavanaki
Aug 26, 2014·Reviews in the Neurosciences·Lauren E Salminen, Robert H Paul
Feb 28, 2020·Journal of Molecular Neuroscience : MN·Marie-Louise MalletPanagiotis Zis
May 13, 2008·The American Journal of Clinical Nutrition·Emmanuelle E FabreValerie Nivet-Antoine
Nov 19, 2020·Pediatric Diabetes·Gulcin AkinciEva L Feldman
Feb 14, 2021·Redox Biology·Bato KoracAleksandra Jankovic
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.