The 2D:4D ratio, a proxy for prenatal androgen levels, differs in men with and without MS

Neurology
Riley BoveTanuja Chitnis

Abstract

To determine whether the 2D:4D ratio (ratio of the second and fourth digit lengths), a proxy for lower prenatal androgen to estrogen ratio, differs in men with and without multiple sclerosis (MS) using a case-control study design. We obtained 2 digital scans of the right hand for men with MS presenting to a scheduled clinic visit at a large MS referral center, and for men without autoimmune or endocrine diseases. All individuals were aged 18 to 65 years, right-handed, and reported no prior digit trauma. We calculated a mean 2D:4D ratio using digital calipers. In participants with MS, we assessed age at first MS symptoms, MS type, and the MS Severity Score; 51 had provided a testosterone level within 10 years of symptom onset. Our primary analysis was a cross-sectional comparison of the 2D:4D ratio between men with and without MS, using a 2-sample t test for independent samples assuming unequal variance. In total, we scanned 137 men with MS and 145 men without MS. A statistically significant association between 2D:4D ratio and MS status was observed in the univariate logistic regression model (p<0.05). These differences were not associated with age or race, which differed between the 2 groups. In participants with MS, the 2D:4D ...Continue Reading

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Citations

Sep 6, 2015·Neurology·Robyn M Lucas, Brenda Banwell
Jan 9, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Tanuja Chitnis
Mar 2, 2018·Evolution, Medicine, and Public Health·Riley M Bove
Jan 18, 2017·Annals of Clinical and Translational Neurology·Tanuja ChitnisUNKNOWN U.S. Network of Pediatric MS Centers
Jul 29, 2020·Frontiers in Neurology·Francesca GilliAndrew R Pachner
Apr 19, 2020·Early Human Development·Sibel GaziogluCavit Boz

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