The 3' untranslated region of prohibitin and cellular immortalization

Experimental Cell Research
Eldon R JupeR T Dell'Orco

Abstract

We have been studying the role of the evolutionarily conserved prohibitin gene in cellular immortalization and tumor suppression. Immortalized human cells are classified into four complementation groups (A, B, C, and D) based on the ability of fusion hybrids to become senescent. The present study expands our preliminary evidence showing that the antiproliferative activity of prohibitin is only effective in immortalized Group B cells and normal cells. Data presented here show that the expression of a prohibitin mRNA with a long 3' untranslated region (3'UTR) and prohibitin protein is elevated in immortalized cells from all complementation groups. However, all immortalized cells classified in complementation Group B, and no cell lines in any of the other groups, are sensitive to the antiproliferative activity of wild-type prohibitin transcripts. All Group B cells are also homozygous for one of two human prohibitin alleles that are distinguishable by two distinct intron polymorphism restriction sites. Interestingly, sequence analysis of the prohibitin gene from representatives of each of the complementation groups showed that the 3'UTR from Groups A, C, and D matched wild type; however, the sequence from all four Group B cell line...Continue Reading

Citations

Jun 7, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dónal O'Carroll, Anne Schaefer
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nish PatelBruce R Zetter
Nov 16, 2010·Nucleic Acids Research·Tim R MercerJohn S Mattick
Nov 12, 2003·Reproductive Biology and Endocrinology : RB&E·Michael FraserBenjamin K Tsang
Dec 2, 2008·PLoS Computational Biology·Marcel E DingerJohn S Mattick
Apr 25, 2009·PLoS Genetics·John S Mattick
May 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Antje Menssen, Heiko Hermeking
Jun 7, 2012·British Journal of Cancer·A JakubowskaUNKNOWN CIMBA, the Consortium of Investigators of Modifiers of BRCA1/2-Related Cancer
Oct 27, 2015·Cell and Tissue Research·Indrajit ChowdhuryWinston E Thompson
Jul 20, 2010·Mitochondrion·Sudharsana R Ande, Suresh Mishra
Jun 6, 2009·The American Journal of Pathology·Paul B RomesserGerald V Denis
Apr 12, 2007·Proteins·Anja WinterAndreas Hofmann
Jun 27, 2006·Journal of Cellular and Molecular Medicine·Suresh MishraLiam J Murphy
Jan 5, 2011·Biochimica Et Biophysica Acta·Anne-Laure Bulteau, Aurelien Bayot
Jun 4, 2013·Cancer Letters·Jun Li, Xin Lu
Jun 21, 2001·Molecular Cell Biology Research Communications : MCBRC·A J Darmon, P S Jat
May 23, 1998·Experimental Cell Research·A J PowellP S Jat
Oct 13, 2010·Current Biology : CB·Margaret S Ebert, Phillip A Sharp
Aug 2, 2011·Biochimie·Marcel E DingerJohn S Mattick
Jul 26, 2011·Biochimie·Malgorzata KlocSriyutha A Reddy
Aug 23, 2002·Biochimica Et Biophysica Acta·Isabel Arnold, Thomas Langer
Sep 22, 2010·PloS One·Claudia SieversThomas Rudel
Mar 19, 2004·Biology of Reproduction·Winston E ThompsonBenjamin K Tsang
Apr 13, 2017·Experimental Biology and Medicine·Suresh Mishra, Bl Grégoire Nyomba
Apr 13, 2005·Trends in Molecular Medicine·Suresh MishraLiam J Murphy
Feb 18, 2004·Oncogene·Simon C GambleCharlotte L Bevan
Oct 8, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Paulo P Amaral, John S Mattick
Jan 14, 2010·Pathology Oncology Research : POR·Hong-Zheng RenXu-zheng Shan
Oct 3, 2002·The Journal of Biological Chemistry·Ksenya ShchorsLouis P Deiss
Feb 23, 2020·Experimental Biology and Medicine·Lucía Barbier-Torres, Shelly C Lu
Sep 28, 2013·Cancer Discovery·Florian A Karreth, Pier Paolo Pandolfi

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