PMID: 9557692Apr 29, 1998Paper

The 30-base-pair deletion in Chinese variants of the Epstein-Barr virus LMP1 gene is not the major effector of functional differences between variant LMP1 genes in human lymphocytes

Journal of Virology
R J JohnsonM Rowe

Abstract

One group of sequence variants of Epstein-Barr virus is characterized by a 10-amino-acid deletion within the CTAR-2 functional domain of the latent membrane protein, LMP1. A role for this deletion in enhancing the tumorigenicity of the viral oncogene in rodent fibroblasts was recently demonstrated. We examined the effect of this deletion upon LMP1 function in four human lymphoid cell lines by using three natural variants of LMP1: the prototype B95.8 gene and the CAO and AG876 genes, both of which have codons 343 to 352 of the B95.8-LMP1 deleted. These experiments revealed that LMP1-mediated upregulation of CD40 and CD54 was markedly impaired (by 60 to 90%) with CAO-LMP1 compared with B95.8-LMP1. In contrast, the function of AG876-LMP1 was indistinguishable from that of B95.8-LMP1 in two lines and was only slightly impaired in the other two lines. Activation of NF-kappaB by CAO-LMP1 was not impaired in any of the lines; rather, activation of an NF-kappaB reporter by CAO-LMP1 was consistently about twofold greater than the activation with B95.8- or AG876-LMP1. Therefore, while the CAO-LMP1 is functionally distinct from the prototype B95.8-LMP1 in human lymphocytes, the 10-amino-acid deletion appears not to be directly responsible...Continue Reading

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Citations

Dec 25, 2003·Journal of Virology·Rachel H EdwardsNancy Raab-Traub
Nov 7, 2008·The Journal of Biological Chemistry·Maria VaysbergOlivia M Martinez
Oct 21, 2011·Journal of Medical Virology·Beata KasztelewiczKatarzyna Dzierżanowska-Fangrat
Apr 9, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ray BridgesPaul J Farrell
Mar 16, 2007·Carcinogenesis·Chrystalla T CharalambousJoanna B Wilson
May 22, 2013·Clinical & Developmental Immunology·J MorscioT Tousseyn
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May 13, 2003·International Journal of Cancer. Journal International Du Cancer·Kai Yu JenTakashi Saku
Mar 18, 2004·International Journal of Cancer. Journal International Du Cancer·Angela Kwok Fung LoSai-Wah Tsao
Jan 31, 2019·Cancer Science·Teru KandaKazufumi Ikuta
Mar 29, 2001·International Journal of Cancer. Journal International Du Cancer·P HahnF A Grässer

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