The 30-year natural history of type 1 diabetes complications: the Pittsburgh Epidemiology of Diabetes Complications Study experience

Diabetes
Georgia PambiancoTrevor J Orchard

Abstract

Declining incidences in Europe of overt nephropathy, proliferative retinopathy, and mortality in type 1 diabetes have recently been reported. However, comparable data for the U.S. and trend data for neuropathy and macrovascular complications are lacking. These issues are addressed using the prospective observational Pittsburgh Epidemiology of Childhood-Onset Diabetes Complications Study. Participants were stratified into five cohorts by diagnosis year: 1950-1959, 1960-1964, 1965-1969, 1970-1974, and 1975-1980. Mortality, renal failure, and coronary artery disease (CAD) status were determined on the complete cohort (n = 906) at 20, 25, and 30 years. Overt nephropathy, proliferative retinopathy, and neuropathy were assessed at 20 and 25 years on the subset of participants with a clinical examination. There was a decreasing trend by diagnosis year for mortality, renal failure, and neuropathy across all time intervals (P < 0.05), with the 1950-1959 cohort having a fivefold higher mortality at 25 years than the 1970s' cohorts. Proliferative retinopathy and overt nephropathy showed nonsignificant declines at 20 years (P < 0.16 and P < 0.13, respectively) and no change at 25 years. CAD event rates, which were lower than the other comp...Continue Reading

References

Apr 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D EllisT J Orchard
Jul 1, 1995·Diabetes·P RossingH H Parving
Jan 6, 1994·The New England Journal of Medicine·M BojestigJ Ludvigsson
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Oct 31, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·M BojestigJ Ludvigsson
Mar 29, 2003·Diabetes Care·Peter HovindHans-Henrik Parving
Jun 28, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Rimei NishimuraUNKNOWN Allegheny County Registry
Aug 28, 2003·Diabetes Care·Jonathan Betz BrownKent H Summers
May 28, 2004·Diabetes Research and Clinical Practice·Brad A SobolewskiTrevor J Orchard
Jan 28, 2005·The New England Journal of Medicine·Solomon TesfayeUNKNOWN EURODIAB Prospective Complications Study Group
Dec 24, 2005·The New England Journal of Medicine·David M NathanUNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research

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Citations

Jul 29, 2009·Archives of Internal Medicine·UNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research GroupTrevor J Orchard
Mar 3, 2007·Diabetologia·G DahlquistUNKNOWN Swedish Childhood Diabetes Study Group
Feb 10, 2009·Diabetologia·E A M Gale
Jun 4, 2011·Diabetologia·H P HammesUNKNOWN DPV-Wiss Study Group
Nov 9, 2012·Diabetologia·M L Alvarez, J K DiStefano
Mar 6, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kevin V Lemley
Mar 31, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kevin V Lemley
Dec 13, 2006·Reviews in Endocrine & Metabolic Disorders·R Paul Wadwa
Apr 29, 2010·Current Diabetes Reports·Trevor J Orchard, Tina Costacou
Aug 2, 2011·Current Diabetes Reports·Marco MariglianoRita Bottino
May 10, 2011·Endocrine·Dilek YazıcıSema Akalın
Mar 27, 2012·Journal of Cardiovascular Translational Research·Tina Costacou, Andrew P Levy
Apr 25, 2012·Journal of Cardiovascular Translational Research·Janet K Snell-Bergeon, Kristen Nadeau
Dec 1, 2008·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Lluís VilaRicardo Alemán
May 20, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·B ConwayT J Orchard
Oct 1, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Alvin C Powers
Apr 5, 2012·Diabetes Technology & Therapeutics·David M Maahs
May 1, 2012·Diabetes Technology & Therapeutics·David M Maahs
Feb 9, 2012·Current Opinion in Nephrology and Hypertension·Merlin C ThomasKarl Tryggvason
May 12, 2010·International Journal of Clinical Practice·P AschnerUNKNOWN Global Partnership for Effective Diabetes Management
Jan 1, 2011·BMJ Case Reports·Ravindranath K ShankarappaVered Molho-Pessach
Sep 10, 2011·BMJ : British Medical Journal·Valma HarjutsaloPer-Henrik Groop
May 5, 2011·American Journal of Physiology. Endocrinology and Metabolism·Justin L Rains, Sushil K Jain
Apr 7, 2010·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Rachel G MillerTrevor J Orchard
Jul 8, 2010·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Catherine T PrinceTrevor J Orchard
Dec 10, 2009·Vascular Health and Risk Management·Daniel J MooreJill H Simmons
Feb 11, 2012·Diabetes Care·Silvana SalardiUNKNOWN Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetology
Feb 9, 2012·International Journal of Molecular Sciences·Hua XinZhong-Cheng Xin
Jan 9, 2014·Current Diabetes Reports·Carolina Solis-HerreraJane L Lynch
Mar 26, 2014·Nature Reviews. Endocrinology·Markku Laakso, Johanna Kuusisto
Jul 2, 2014·Current Opinion in Endocrinology, Diabetes, and Obesity·Petter BjornstadDavid M Maahs
Sep 5, 2014·Diabetologia·Sabita S Soedamah-MuthuTrevor J Orchard

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