The 3'UTR NFKBIA variant is associated with extensive colitis in Hungarian IBD patients.

Digestive Diseases and Sciences
Tamás SzamosiHajnalka Andrikovics

Abstract

In previous studies the NFKBIA 3'UTR (untranslated region) AA genotype was associated with Crohn's disease (CD), while the NFKB1-94ins/delATTG mutation increased the risk for ulcerative colitis (UC). The aim of our study was to investigate these two polymorphisms and patients' response to medical therapy and/or disease phenotype in Hungarian inflammatory bowel disease (IBD) patients. NFKBIA 3'UTR- and NFKB1-94ins/delATTG polymorphisms were investigated in 415 unrelated IBD patients (CD: 266 patients, mean age 35.2 +/- 12.1 years, duration 8.7 +/- 7.5 years; UC patients: 149, mean age 44.4 +/- 15.4 years, duration 10.7 +/- 8.9 years) and 149 controls by PCR-restriction fragment length polymorphism (RFLP) analysis. Detailed clinical phenotypes were determined by reviewing the medical charts. The NFKBIA 3'UTR and NFKB1-94ins/delATTG genotypes and allele frequencies were not significantly different among IBD and controls. In patients with UC, the 3'UTR GG genotype was associated with extensive colitis (55.3 vs. 29.4%, odds ratio 2.97, 95% confidence interval 1.45-6.08). The presence of variant alleles did not predict response to steroids, infliximab, or need for surgery. The NFKBIA 3'UTR GG genotype was associated with an increased...Continue Reading

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Citations

Jun 18, 2011·Pathology Oncology Research : POR·Laszlo BeneAndras Kristof Fulop
May 25, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Guo-Long ZhangQing Zhou
Nov 5, 2014·British Journal of Haematology·Gergely VargaTamás Masszi
Aug 5, 2016·Journal of Human Genetics·Maneesh Kumar MisraSuraksha Agrawal
Dec 14, 2018·International Immunopharmacology·Lei ZhuHong Shen

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