The 4-hydroxyestrone: Electron emission, formation of secondary metabolites and mechanisms of carcinogenesis.

Journal of Photochemistry and Photobiology. B, Biology
Nikola GetoffRuth Maria Quint

Abstract

4-Hydroxyestrone (4-OHE(1)), a typical cancer-inducing metabolite, originating from 17beta-estradiol (17beta-E2), was chosen as a model for the studies. The aim was to get a deeper insight in the mechanisms of its ability to initiate cancer. It was found, that 4-OHE(1) can eject electrons (e(aq)(-)), when excited in the singlet state by monochromatic UV-light (lambda=254 nm) in polar media (water:ethanol=40:60 vol.%). The quantum yield Q(e(aq)(-)), determined for various 4-OHE(1) concentrations, is found to be as high as that previously observed for 17beta-E2. It decreases with increasing substrate concentration, but it is enhanced at higher temperature. The ability of 4-OHE(1) to eject as well as to consume and to transfer electrons to other biological systems, classifies it as an electron mediator, similar to 17beta-E2. The 4-OHE(1) transients resulting of the electron emission process are leading to the formation of secondary metabolites. Surprisingly, it was established that the secondary metabolites possess likewise the ability to eject as well as to consume electrons. Hence, they behave similar like 17beta-E2. However, the structure of the secondary formed metabolites, which determinates their biological properties and ca...Continue Reading

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May 24, 2008·Journal of Photochemistry and Photobiology. B, Biology·Nikola GetoffRuth Maria Quint
Jan 7, 2009·Journal of Photochemistry and Photobiology. B, Biology·Nikola GetoffRuth Maria Quint

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Citations

Jan 14, 2012·Chemosphere·Yasmine SouissiMichel Sablier
Apr 13, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nikola GetoffRuth-Maria Quint
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Somsak LikhitrattanapisalTavan Janvilisri
Jul 1, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Marion GerschpacherRuth M Quint

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