The 460Trp allele of alpha-adducin increases carotid intima-media thickness in young adult males

Journal of Hypertension
R SarzaniA Rappelli

Abstract

The 460Trp allele of the alpha-adducin gene (ADD1), which is involved in a form of salt-sensitive hypertension, has been associated with patterns of target organ damage. As carotid artery intima-media thickness (IMT) largely depends upon unknown genetic factors, besides being associated to conventional risk factors, we tested the association of the 460Trp allele of ADD1 with IMT in a well-characterized sample of young healthy normotensive subjects, to assess the role of ADD1 polymorphism without overlapping effects of age or already elevated blood pressure. Anthropometric measurements, blood pressure (BP), and carotid artery wall IMT (high-resolution sonography and digitalized morphometry) were obtained in 420 healthy normotensive Caucasian university students. Genotypes for ADD1 were detected by automated genomic polymerase chain reaction (PCR). ADD1 genotypes were evenly distributed between genders. IMT was significantly larger in carriers of the 460Trp allele of ADD1, while a significant gender x ADD1 interaction (P = 0.02) demonstrated that IMT was increased only in males carrying the 460Trp allele (P < 0.001). No significant association was found in females. The 460Trp allele of ADD1 contributes substantially to increase c...Continue Reading

References

Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·G BianchiM Ferrandi
May 1, 1996·Stroke; a Journal of Cerebral Circulation·R DuggiralaJ Blangero
Jul 27, 2000·American Journal of Hypertension·M A ProvinceR R Williams
Aug 10, 2000·Journal of Hypertension·A M Sharma, X Jeunemaitre
Aug 19, 2000·Cellular and Molecular Life Sciences : CMLS·Y MatsuokaV Bennett
Mar 7, 2001·Hypertension·M H WeinbergerM Weinberger
Nov 29, 2001·Journal of Hypertension·R SarzaniA Rappelli
Dec 1, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J G WangG Bianchi
Mar 21, 2002·Clinical and Experimental Pharmacology & Physiology·F ZannadS Visvikis
Apr 3, 2002·JAMA : the Journal of the American Medical Association·Bruce M PsatyFrits R Rosendaal
Jun 8, 2002·Hypertension·Alanna C MorrisonEric Boerwinkle
Aug 13, 2002·Journal of Hypertension·Elisabeth J BalkesteinJan A Staessen
Aug 27, 2002·Journal of Hypertension·Mikolaj WinnickiUNKNOWN HARVEST Study Group
Jun 5, 2003·Journal of Hypertension·UNKNOWN European Society of Hypertension-European Society of Cardiology Guidelines Committee
Jun 14, 2003·Stroke; a Journal of Cerebral Circulation·Fakhredin A Sayed-TabatabaeiJacqueline C M Witteman
Jan 6, 2004·Journal of Human Hypertension·R SarzaniA Rappelli
Jan 13, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Steve E HumphriesPhilippa J Talmud
Apr 9, 2004·The Proceedings of the Nutrition Society·Philippa J Talmud
Jul 17, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Teri A ManolioAlexander F Wilson
Dec 1, 2004·Stroke; a Journal of Cerebral Circulation·Susanna MoskauThomas Klockgether
Feb 9, 2005·Hypertension·Giuseppe BianchiJan A Staessen

❮ Previous
Next ❯

Citations

Jan 4, 2013·PloS One·Shuzhen GuoEng H Lo
May 24, 2008·American Journal of Hypertension·Riccardo SarzaniAlessandro Rappelli
Feb 22, 2008·Journal of Human Hypertension·R SarzaniA Rappelli
May 2, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Damiano RizzoniEnrico Agabiti Rosei
Jan 5, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jayantee KalitaUsha K Misra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

© 2021 Meta ULC. All rights reserved