The 5 alpha-reductase system and its inhibitors. Recent development and its perspective in treating androgen-dependent skin disorders

Dermatology : International Journal for Clinical and Investigative Dermatology
W ChenC E Orfanos

Abstract

5 alpha-Reductase, the enzyme system that metabolizes testosterone into dihydrotestosterone, occurs in two isoforms. The type 1 isozyme is composed of 259 amino acids, has an optimal pH of 6-9 and represents the 'cutaneous type'; it is located mainly in sebocytes but also in epidermal and follicular keratinocytes, dermal papilla cells and sweat glands as well as in fibroblasts from genital and non-genital skin. The type 2 isozyme is composed of 254 amino acids, has an optimal pH of about 5.5 and is located mainly in the epididymis, seminal vesicles, prostate and fetal genital skin as well as in the inner root sheath of the hair follicle and in fibroblasts from normal adult genital skin. The genes encoding type 1 and type 2 isozymes are found in chromosomes 5p and 2p, respectively, and each consists of 5 exons and 4 introns. During the last decade, several steroid analogues and non-steroid agents have been developed to interfere with 5 alpha-reductase activity. Finasteride, which has a higher affinity for the type 2 isozyme, is the first 5 alpha-reductase antagonist clinically introduced for treatment of benign prostate hyperplasia. The clinical evaluation of finasteride or other 5 alpha-reductase inhibitors in the field of derm...Continue Reading

Citations

Jun 16, 1999·International Journal of Dermatology·D de Berker
Apr 20, 2001·The Journal of Veterinary Medical Science·E IwataY Mori
Oct 12, 2001·Seminars in Cutaneous Medicine and Surgery·D Thiboutot
Nov 11, 2003·Clinical Pharmacokinetics·Andrea Krautheim, Harald Gollnick
Dec 29, 2007·Pharmaceutical Development and Technology·Rajiv KumarOm Prakash Katare
Apr 9, 2008·Dermatologic Therapy·A Katsambas, C Dessinioti
Feb 17, 2009·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Ryoji Tsuboi
May 27, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ruchy JainWanchai De-Eknamkul
Feb 20, 2016·The Journal of Dermatology·Yuichiro TsunemiUNKNOWN ARI114264 Study Group
Jul 26, 2012·Archives of Dermatological Research·Jiann-Jyh LaiChawnshang Chang
May 21, 2020·Journal of Cosmetic Dermatology·Elisete Isabel CroccoSamara Eberlin
Jan 13, 2000·International Journal of Dermatology·S Brenner, H Matz
May 26, 2007·Journal of Cosmetic Dermatology·Hristo Dobrev
May 21, 2008·International Journal of Cosmetic Science·J M BrandnerI Moll
May 31, 2014·Expert Opinion on Therapeutic Targets·Ruchy Jain, Wanchai De-Eknamkul
Dec 14, 2019·American Journal of Clinical Dermatology·Dustin H MarksMaryanne M Senna
Nov 13, 2001·American Journal of Clinical Dermatology·C Bolduc, J Shapiro
Jun 16, 1999·International Journal of Dermatology·A Tosti, B M Piraccini
Nov 24, 1999·International Journal of Dermatology·A F AlexisM J Stiller
Aug 26, 2006·Skin Pharmacology and Physiology·A WiniarskaU Blume-Peytavi
Jun 4, 2014·Expert Opinion on Investigational Drugs·Isabel Cristina Valente Duarte de Sousa
Apr 4, 2019·International Journal of Molecular Medicine·Ju Hee KimHyun-Shik Lee
Mar 9, 2019·Expert Opinion on Pharmacotherapy·Isabel Cristina Valente Duarte De Sousa
Aug 8, 2001·The Australasian Journal of Dermatology·N Wines, E Willsteed
Jan 9, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Nikolaos NikolaouJeremy W Tomlinson
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shakeel IjazJohn J Walsh
May 12, 2001·The Journal of Investigative Dermatology·M FritschC C Zouboulis
Nov 26, 2002·The Journal of Investigative Dermatology·WenChieh ChenChristos C Zouboulis
May 20, 1998·Dermatologic Clinics·J Shapiro, V H Price
Feb 16, 2006·Molecular and Cellular Endocrinology·Bernard Robaire, Natali A Henderson
Aug 14, 1998·Journal of the American Academy of Dermatology·W F Bergfeld

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