PMID: 8971795Nov 22, 1996Paper

The 5-HT1A antagonist WAY-100635 selectively potentiates the presynaptic effects of serotonergic antidepressants in rat brain

Neuroscience Letters
L RomeroF Artigas

Abstract

The increases in extracellular serotonin (5-hydroxytryptamine; 5-HT) produced by some antidepressent drugs in forebrain are attenuated by the activation of somatodendritic 5-HT1A autoreceptors by the excess 5-HT induced by these agents in the midbrain raphe. Using microdialysis, we have examined the effects of the selective 5-HT1A antagonist WAY-100635 in rats pretreated with the selective 5-HT reuptake inhibitors (SSRIs) citalopram, fluoxetine, fluvoxamine, the tricyclic antidepressants clomipramine and desipramine and the monoamine oxidase inhibitor phenelzine. WAY-100635 markedly potentiated the increases in 5-HT produced by the SSRIs, clomipramine and phenelzine but it did not alter that produced by desipramine. These results indicate that the effects of serotonergic antidepressant drugs (but not those of desipramine, which mainly blocks noradrenaline reuptake) can be potentiated by 5-HT1A autoreceptor blockade.

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Jan 1, 1991·Journal of Receptor Research·D Hoyer, P Schoeffter
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Citations

Aug 13, 2010·Psychopharmacology·Agnieszka Pałucha-PoniewieraAndrzej Pilc
Nov 26, 2002·European Journal of Pharmacology·Minke E JongsmaJakob Korf
Dec 25, 2002·European Journal of Pharmacology·Masaki SakaueToshio Matsuda
Jun 18, 2003·European Journal of Pharmacology·Anna WesołowskaEwa Chojnacka-Wójcik
Nov 11, 1998·European Journal of Pharmacology·I Hervás, F Artigas
Jun 22, 1999·European Journal of Pharmacology·E GurM E Newman
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·Mariusz PappConnie Sánchez
May 22, 2003·Pharmacology, Biochemistry, and Behavior·A S IvyA A Russo-Neustadt
Jun 12, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Omar M E Abdel-SalamSiham M El-Shenawy
Jun 20, 2008·Journal of Psychopharmacology·P FengK P Strohl
Aug 26, 1999·Neuropharmacology·N M Barnes, T Sharp
Sep 22, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Leandro C SouzaCristiano R Jesse
Nov 2, 2014·The Journal of Sexual Medicine·Trynke R de Jong, Inga D Neumann
Jul 17, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Robert L GannonMark J Millan
Nov 26, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Lucimar M Pinto BrodLucielli Savegnago
Sep 18, 2004·Brain Research·Andréa Dias Elpo ZomkowskiAna Lúcia Severo Rodrigues
Apr 5, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lucjan StrekowskiAndrzej J Bojarski
Jan 17, 2015·European Journal of Pharmacology·S Mechiel KorteBerend Olivier
Apr 10, 2012·Pharmacology, Biochemistry, and Behavior·Mariana Freire Barbieri GerzsonLucielli Savegnago
Apr 18, 2014·Expert Opinion on Drug Discovery·Laura Perez-CaballeroEsther Berrocoso
Sep 6, 2005·European Journal of Pharmacology·Yukio AgoToshio Matsuda
Jan 29, 2013·Brain Research Bulletin·Mauricio P CunhaAna Lúcia S Rodrigues
Mar 16, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·S PorcelliA Serretti
Feb 23, 2010·Pharmacology, Biochemistry, and Behavior·Güner UlakB Faruk Erden

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