The 5-HT1A receptor is not involved in emotional stress-induced rises in stress hormones

Pharmacology, Biochemistry, and Behavior
L GroeninkB Olivier

Abstract

To determine whether emotional stress-induced rises in stress hormone levels are mediated by activation of 5-HT1A receptors, we studied the effects of the selective 5-HT1A receptor antagonist, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexanecarboxamide trihydrochloride (WAY-100635) on plasma ACTH, corticosterone, prolactin, and glucose levels in the conditioned ultrasonic vocalisation (USV) model in adult rats. The effects of WAY-100635 on USVs were also investigated in this paradigm. WAY-100635 (0.3, 1, and 3 mg/kg SC) had no clear effects on basal plasma ACTH, corticosterone, and glucose levels, but the 3 mg/kg dose significantly increased the plasma prolactin levels. The increases in plasma ACTH, corticosterone, and prolactin levels induced by the USV procedure were not affected by WAY-100635. This indicates that the 5-HT1A receptor does not play a major role in the distress-induced activation of the hypothalamic-pituitary-adrenal axis and prolactin secretion. The USVs were significantly enhanced by low doses of WAY-100635 (0.03 and 0.3 mg/kg SC), whereas higher doses (1.0 and 3.0 mg/kg SC) had no effect. These findings suggest that blockade of 5-HT1A receptors during stress may enhance the behaviou...Continue Reading

References

Jul 1, 1992·Neuropharmacology·K J KellarC M Flores
May 4, 1984·Science·J Axelrod, T D Reisine
Apr 1, 1995·Psychopharmacology·S B Park, P J Cowen
Jan 1, 1993·Brain Research. Brain Research Reviews·F Chaouloff
Jul 25, 1995·European Journal of Pharmacology·E A ForsterA Fletcher

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Citations

Apr 12, 2001·Biological Psychiatry·T PattijB Olivier
Feb 26, 2003·European Journal of Pharmacology·Connie Sánchez
Feb 26, 2003·European Journal of Pharmacology·Lucianne GroeninkBerend Olivier
Feb 26, 2003·European Journal of Pharmacology·Gonzalo A Carrasco, Louis D Van de Kar
Apr 18, 1997·European Journal of Pharmacology·J C CompaanB Olivier
Jul 4, 1998·European Journal of Pharmacology·A VicenticL D Van de Kar
Sep 6, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Femke T A PijlmanJan M van Ree
Dec 14, 2001·Behavioural Pharmacology·B OlivierM Toth
Nov 7, 1998·Brain Research·H JørgensenJ Warberg
May 12, 2009·Journal of Behavior Therapy and Experimental Psychiatry·Muriel A HagenaarsMarc Verbraak
Dec 3, 2014·European Journal of Pharmacology·Berend Olivier
Sep 11, 2012·Consciousness and Cognition·Chris R BrewinJessica Colson
Mar 19, 2014·Neuroscience and Biobehavioral Reviews·Cedric B P MartinRaymond Mongeau
Feb 26, 2004·Journal of Experimental Psychology. General·Emily A HolmesRichard G Hennessy
Jan 4, 2012·Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)·Bethany L BrandDavid Spiegel
Apr 10, 1999·The Australian and New Zealand Journal of Psychiatry·O van der HartM Graafland

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