The 5-HT2C receptor agonist meta-chlorophenylpiperazine (mCPP) reduces palatable food consumption and BOLD fMRI responses to food images in healthy female volunteers

Psychopharmacology
Jason M ThomasSuzanne Higgs

Abstract

Brain 5-HT2C receptors form part of a neural network that controls eating behaviour. 5-HT2C receptor agonists decrease food intake by activating proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus, but recent research in rodents has suggested that 5-HT2C receptor agonists may also act via dopaminergic circuitry to reduce the rewarding value of food and other reinforcers. No mechanistic studies on the effects of 5-HT2C agonists on food intake in humans have been conducted to date. The present study examined the effects of the 5-HT2C receptor agonist meta-chlorophenylpiperazine (mCPP) on food consumption, eating microstructure and blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) responses to food pictures in healthy female volunteers. In a double-blind, placebo-controlled, crossover design, participants were randomized immediately after screening to receive oral mCPP (30mg) in a single morning dose, or placebo, in a counterbalanced order. Test foods were served from a Universal Eating Monitor (UEM) that measured eating rate and fMRI BOLD signals to the sight of food and non-food images were recorded. mCPP decreased rated appetite and intake of a palatable snack eaten in th...Continue Reading

References

Jun 1, 1988·Journal of Personality and Social Psychology·D WatsonA Tellegen
Jan 1, 1985·Journal of Psychosomatic Research·A J Stunkard, S Messick
Jan 1, 1974·Modern Problems of Pharmacopsychiatry·D von ZerssenD Schwarz
Sep 17, 1971·Science·M Cabanac
May 1, 1995·Psychopharmacology·S C AronsonL H Price
Sep 1, 1994·Psychopharmacology·A E WalshP J Cowen
Apr 1, 1994·Brain Research. Molecular Brain Research·M PompeianoG Mengod
Nov 1, 1995·Journal of Clinical Psychology·J H PattonE S Barratt
Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Jan 26, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·D MarazzitiG B Cassano
Jul 27, 2002·Science·Lora K HeislerJoel K Elmquist
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Dec 11, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul J FletcherGuy A Higgins
Jul 19, 2006·Neuron·Lora K HeislerMichael A Cowley
Mar 21, 2007·Neuroscience·M J Bubar, K A Cunningham
Aug 11, 2007·Science·I Sadaf FarooqiPaul C Fletcher
Dec 25, 2007·NeuroImage·Gene-Jack WangNora D Volkow
May 8, 2008·Cell Metabolism·Saima MalikAlain Dagher
Sep 5, 2009·European Journal of Endocrinology·Helen Butler, Márta Korbonits
Oct 9, 2009·The European Journal of Neuroscience·Anthony P GoldstoneJimmy D Bell
Dec 10, 2009·The Journal of Clinical Endocrinology and Metabolism·Martina GuthoffAndreas Fritsche
Oct 11, 2011·Current Opinion in Neurobiology·Hans-Rudolf Berthoud
Jan 10, 2012·Trends in Cognitive Sciences·Clay B Holroyd, Nick Yeung
Nov 28, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarah Rudorf, Todd A Hare
Mar 5, 2016·Current Opinion in Behavioral Sciences·Mark E WaltonSteven W Kennerley

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Citations

Jul 25, 2019·PeerJ·Dana L M CampbellCaroline Lee
May 16, 2020·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Anna Welz, Marcin Koba
Aug 31, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Elizabeth SchneiderColin T Dourish

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Methods Mentioned

BETA
Chip

Software Mentioned

Featquery
Sussex Ingestion Pattern Monitor ( SIPM )
AFNI
FMRIB
FMRIB FSL
WFUPickatlas
AlphaSim
FLAME
MELODIC
SIPM

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