The 5-HT3 receptor agonist attenuates the action of antidepressants in the forced swim test in rats

Brain Research
Y NakagawaT Takashima

Abstract

Involvement of 5-hydroxytryptamine (5-HT)3 receptors in action of antidepressants was examined in the forced swim test in rats. Rats were forced to swim in a cylinder for 15 min on day 1 and for 5 min on day 2. Imipramine, desipramine and mianserin, administered after the 15-min swim session on day 1 and before the 5-min swim test on day 2, dose-dependently decreased the duration of immobility in the swim test on day 2. 1-(m-Chlorophenyl)-biguanide (mCPBG) attenuated the decreased duration of immobility induced by imipramine, desipramine and mianserin, although mCPBG did not affect the duration of immobility when it was given alone. ICS205-930 dose-dependently decreased the duration of immobility in the swim test on day 2, and the effect of ICS205-930 was attenuated by mCPBG. These results suggest that the suppression of 5-HT3 receptor activity may contribute to the action of antidepressants.

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Citations

Nov 26, 2010·Psychopharmacology·Gregory V Carr, Irwin Lucki
Oct 6, 2007·Molecular Neurobiology·Gerhard Rammes, Rainer Rupprecht
Oct 21, 1999·European Journal of Pharmacology·Y NakagawaT Takashima
Aug 31, 2001·Pharmacology, Biochemistry, and Behavior·J EguchiK Saito
Feb 29, 2016·Pharmacological Reports : PR·Karolina PytkaBarbara Filipek
Oct 2, 2012·Pharmacology & Therapeutics·Francesc Artigas
Mar 17, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Daniele G MachadoAna Lúcia S Rodrigues
Apr 29, 2008·Neuroscience and Biobehavioral Reviews·Andrew Holmes
Oct 31, 2002·Human Psychopharmacology·John F. Cryan, Brian E. Leonard
Nov 18, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·T KosA Y Bespalov
Feb 4, 2010·Journal of Psychopharmacology·Ramamoorthy Rajkumar, Radhakrishnan Mahesh
Dec 4, 2003·Molecular Psychiatry·B EisensamerR Rupprecht
Feb 3, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H MiwaJ Watari
Mar 3, 2020·Medicinal Research Reviews·Radomir JuzaJan Korabecny
Mar 29, 2011·Pharmacological Reports : PR·Jacek SapaBarbara Malawska
Aug 28, 2021·International Journal of Molecular Sciences·Grzegorz ŚlifirskiJadwiga Turło

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