The 5-HT3A receptor is essential for fear extinction

Learning & Memory
Makoto KondoShoichi Shimada

Abstract

The 5-HT3 receptor, the only ionotropic 5-HT receptor, is expressed in limbic regions, including the hippocampus, amygdala, and cortex. However, it is not known whether it has a role in fear memory processes. Analysis of 5-HT3A receptor knockout mice in fear conditioning paradigms revealed that the 5-HT3A receptor is not required for the acquisition or retention of fear memory but is essential for the extinction of contextual and tone-cued fear. Our data suggest that the 5-HT3A receptor could be a key molecule regulating fear memory processes and a potential therapeutic target for fear disorders.

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Citations

Mar 10, 2017·Scientific Reports·Yoshihisa KoyamaShoichi Shimada
Aug 18, 2017·Learning & Memory·René Garcia
Jul 30, 2016·The Journal of Biological Chemistry·Amrutha SwaminathanTapas K Kundu
Aug 20, 2019·The European Journal of Neuroscience·Jochen WintererCsaba Földy
Apr 4, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kazuya OhataShoichi Shimada
Sep 28, 2021·Trends in Neurosciences·Rebecca A Senft, Susan M Dymecki

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