The 5-HTTLPR confers susceptibility to anorexia nervosa in Han Chinese: evidence from a case-control and family-based study

PloS One
Jue ChenChen Zhang

Abstract

Accumulating evidence has implied that serotonin system dysfunction may be involved in the etiology of anorexia nervosa (AN). Serotonin-transporter-linked promoter region (5-HTTLPR) polymorphism is the genetic variant coding for the serotonin transporter and has a modulatory effect on its expression. This study aimed to investigate the possible association between the 5-HTTLPR and the susceptibility and severity of AN in Han Chinese using a case-control (255 patients and 351 controls) and family based study (198 trios). Eating disorder examination was used to measure the severity of AN behavioral symptoms. For the case-control study, the 5-HTTLPR showed significant association with AN in our sample (genotypic P = 0.03). The frequency of S allele was significantly higher in patients than that in controls (OR = 1.38, 95%CI: 1.06-1.79, P = 0.017). For the family-based study, the S allele of 5-HTTLPR was preferentially transmitted rather than non-transmitted from the parents to affected offspring (P = 0.013). The results of ANCOVA test revealed no significant association between the 5-HTTLPR polymorphism and severity of AN. Our findings suggested that 5-HTTLPR is able to confer susceptibility to AN in Han Chinese.

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Citations

Mar 6, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Pei-an Betty Shih, D Blake Woodside
May 6, 2020·Molecular Genetics & Genomic Medicine·Stefano PaolacciMatteo Bertelli
Aug 13, 2020·Eating and Weight Disorders : EWD·Sirine Abou Al HassanLama Mattar
Jul 16, 2021·Frontiers in Molecular Neuroscience·Kate BeecherSelena E Bartlett

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

Quanto
Haploview
SPSS
EDE

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