PMID: 2510403Nov 1, 1989Paper

The 5' region of Tacaribe virus L RNA encodes a protein with a potential metal binding domain

Virology
S IapalucciM T Franze-Fernández

Abstract

We have just completed the Tacaribe arenavirus (TV) genome structure by sequencing the 5' region of the L RNA. Analysis of the sequence has indicated the existence of an open reading frame (ORF) in the viral sense RNA encoding a 95 amino acid polypeptide. The first in phase AUG codon is in positions 70-72 from the 5' end of the viral RNA surrounded by a sequence favorable for the initiation of protein synthesis. The ORF ends at positions 355-357. The predicted polypeptide (P11) contains a cysteine-rich sequence bearing a remarkable similarity to the "zinc finger" sequences found in a number of proteins. We have recently reported that the 3' region of the TV L RNA encodes a polypeptide comprising 2210 amino acids in the viral-complementary sequence. This latter gene, i.e., the L gene, terminates at positions 442-440 from the 5' end of the viral RNA. The two genes encoded by the L RNA (L and P11) are in opposite strands of the RNA in sequences that do not overlap, but are separated by a noncoding intergenic region of 82 nucleotides. The nucleotide sequence of the intergenic region leads to the prediction of a strong secondary structure.

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Citations

Jul 1, 1996·Research in Virology·C RossiM T Franze-Fernández
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R LoveringP S Freemont
Oct 1, 2011·Journal of Virology·Maria Eugenia LoureiroNora Lopez
Sep 13, 2003·Journal of Virology·Rodrigo JácamoMaría T Franze-Fernández
Jul 24, 2010·Journal of Biomedicine & Biotechnology·S E GoñiM E Lozano
Feb 20, 2004·Virology·Simon ViethStephan Günther
Apr 16, 2004·Virus Research·Maria N B Cajimat, Charles F Fulhorst
Jun 1, 1992·Virology·I S Lukashevich
Jul 20, 2000·Antiviral Chemistry & Chemotherapy·C C GarcíaE B Damonte
Apr 20, 2010·The Journal of Biological Chemistry·Jean-Baptiste MarqDominique Garcin
May 29, 2020·Archives of Virology·Julia HolzerlandAllison Groseth
Jun 11, 1993·Annals of the New York Academy of Sciences·P S Freemont
Dec 1, 1990·Journal of Virology·D Garcin, D Kolakofsky
Oct 1, 1990·Journal of Virology·D HackerD Kolakofsky
May 1, 1991·Virology·S IapalucciM T Franze-Fernández

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