PMID: 7336163Aug 1, 1981Paper

The 5q- chromosome in preleukaemia and acute leukaemia

Scandinavian Journal of Haematology
L TeerenhoviP Vuopio

Abstract

13 patients with the 5q- chromosome are described. In 6 patients the 5q- chromosome was the sole aberration. 10 patients had preleukaemia, 1 a preleukaemia-like syndrome after treatment of polycythaemia vera, a 2 acute myeloid leukaemia. The prognosis was especially poor in terms of survival in preleukaemic patients with 3 or more affected chromosomes: none of these 6 patients survived for more than 6 months. In 4 patients the haematological picture resembled 'the 5q- syndrome'. In the long arm of chromosome No 5 deletions of 3 different kinds were detected. They were named according to the size of the 5q- marker: the short type (10 patients), the intermediate type (1 patient) and the long type (2 patients). There was no clear correlation between the clinical picture and the type of deletion. While the break points cannot always be exactly defined, our data and those reviewed from the literature suggest that the loss of a segment of regions 5q2 or 5q3 is common to all or most deletions.

References

Jan 13, 1977·Nature·P RuutuA de la Chapelle
Nov 1, 1979·Annals of Internal Medicine·H G Jume'an, J A Libnoch
Jan 1, 1979·Human Genetics·E L PrigoginaI S Peterson
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Citations

Nov 1, 1988·European Journal of Haematology·T ThiedeR Billström
Mar 1, 1989·European Journal of Haematology·M GygerM Desy
Nov 1, 1983·American Journal of Hematology·L P Wisniewski, K Hirschhorn
Apr 1, 1984·Scandinavian Journal of Haematology·T RuutuS Knuutila
Jan 1, 1988·Medical and Pediatric Oncology·E BrusamolinoC Bernasconi
Jan 1, 1991·Clinical and Laboratory Haematology·M LishnerI D Dube
Jul 1, 1985·Cancer Genetics and Cytogenetics·H Van den BergheG Tricot

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