The α6 nicotinic acetylcholine receptor subunit influences ethanol-induced sedation.

Alcohol
Helen M KamensMarissa A Ehringer

Abstract

Alcohol and nicotine are often co-used and data from human and animals studies have demonstrated that common genes underlie responses to these two drugs. Recently, the genes that code for the subunits of the nicotinic acetylcholine receptors have been implicated as a common genetic mediator for alcohol and nicotine responses. The mammalian genes that code for the α6 and β3 subunits of the nicotinic acetylcholine receptor (Chrna6 and Chrnb3, respectively) are located adjacent to each other on human and mouse chromosome 8. These subunits have gained attention as potential regulators of drug behaviors because of their expression in the striatum where they have been shown to modulate dopamine release. Human genetic studies have shown that variation in these genes is associated with alcohol phenotypes. In the current experiments, mice lacking the Chrna6 or Chrnb3 gene were tested for three ethanol behaviors: choice ethanol consumption, ataxia, and sedation. Wildtype (WT), heterozygous (HET), and knockout (KO) mice of each strain went through a standard 2-bottle choice drinking paradigm, the balance beam, and the Loss of Righting Reflex (LORR) paradigm. No genotypic effects on any of the 3 behavioral tasks were observed in Chrnb3 ani...Continue Reading

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Citations

Nov 13, 2012·Biological Psychiatry·Liwang LiuAndrew R Tapper
Jan 5, 2016·Alcoholism, Clinical and Experimental Research·Cassandra A SlaterImad M Damaj
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Aug 6, 2017·Brain Research Bulletin·Helen M KamensCarley N Miller

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