The 7-year cumulative incidence of cornea guttata and morphological changes in the corneal endothelium in the Reykjavik Eye Study

Acta Ophthalmologica
Gunnar M ZoegaFridbert Jonasson

Abstract

To examine the corneal endothelium and establish the 7-year cumulative incidence of cornea guttata (CG). Population-based prospective cohort study with 573 participants (third wave of the Reykjavik Eye Study (RES) in 2008). Four hundred and thirty-seven subjects had either right or left eyes available for analysis after excluding confounding eye conditions. The baseline for eyes at risk for developing CG is the second wave of the RES in 2001. Participants underwent specular microscopy and a standardized eye examination. The cumulative 7-year incidence of CG in either eye was estimated as a 95% confidence interval for the expected value for both genders combined (15-23%), for males (8-18%) and for females (19-29%). In right eye only, the 7-year cumulative incidence for both genders combined was estimated to be 6-11%. For genders combined and for males only, the data indicated no correlation between 7-year cumulated incidence and age at baseline. In women, however, the change of 7-year incidence for CG in at least one eye appeared to be correlated to age at baseline. Reduction of endothelial cell density for corneas with CG at baseline was found [CI (0.95)-132 ± 94]. The cumulative 7-year incidence of primary central CG for a mid...Continue Reading

References

Sep 1, 1993·Survey of Ophthalmology·A P AdamisR C Tripathi
Nov 30, 2002·Journal of Cataract and Refractive Surgery·David T VromanEsther M Bowie
Mar 6, 2003·Archives of Ophthalmology·Fridbert JonassonAlan C Bird
Apr 30, 2003·American Journal of Ophthalmology·Josef AmannHenry F Edelhauser
Feb 14, 2006·Journal of Cataract and Refractive Surgery·Majid MoshirfarPaul C Kang
Apr 4, 2006·Ophthalmology·Gunnar M ZoegaFridbert Jonasson
Mar 29, 2007·The British Journal of Ophthalmology·R L NiedererC N J McGhee

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Citations

Jul 25, 2013·Investigative Ophthalmology & Visual Science·Xiaolin ZhangUNKNOWN Fuchs' Genetics Multi-Center Study Group
Nov 28, 2018·Investigative Ophthalmology & Visual Science·Esam T Ahmed MohamedNico F Declercq
Apr 11, 2019·Journal of Cataract and Refractive Surgery·Andreas VibergBerit Byström
May 22, 2020·Progress in Retinal and Eye Research·Stephan Ong ToneUla V Jurkunas
Feb 18, 2021·Experimental Eye Research·Lauren J JeangEdgar M Espana
Sep 26, 2020·Progress in Retinal and Eye Research·Marianne O PriceFrancis W Price
Jun 23, 2021·Klinische Monatsblätter für Augenheilkunde·Tarek SafiBerthold Seitz
Oct 14, 2021·Acta Ophthalmologica·Andreas VibergBerit Byström

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