The 70-Gene Signature as Prognostic Factor for Elderly Women with Hormone Receptor-Positive, HER2-Negative Breast Cancer.

Breast Care
Steffi HartmannToralf Reimer

Abstract

BACKGROUND: The aim of this article was to evaluate the prognostic value of the MammaPrint(TM) signature in women $ 60 years with invasive breast cancer. PATIENTS AND METHODS: 60 female patients were included in this prospective study. Eligibility criteria included: pT1c-3, pN0-1a, grade 2/3, hormone receptor-positive and HER2-negative tumor. The clinical risk was determined by Adjuvant! Online (AOL). RESULTS: 38 patients (63%) where considered to be low-risk patients by the 70-gene signature, while 22 (37%) were considered to be high-risk patients. No statistically significant differences between low- and high-risk groups could be detected for conventional prognostic parameters, particularly not for Ki-67. By AOL, 33 patients (55%) were considered to be at high risk, of which 20 had a discordant MammaPrint(TM) result. The discordance rate between the profile and AOL was 48%, which is higher than in previous publications. When the 70-gene signature was used in combination with the clinical risk assessment, the recommendation for adjuvant systemic treatment differed in 11 patients (18%). CONCLUSIONS: In the intermediate-risk subgroup, the 70-gene signature could be useful to decide in elderly patients whether they may benefi...Continue Reading

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Citations

Aug 19, 2014·Critical Reviews in Oncology/hematology·Séverine GuiuMaryse Fiche
Sep 13, 2014·Expert Review of Pharmacoeconomics & Outcomes Research·Miguel Ángel SeguíAlfredo Gracia
Oct 15, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P F HalloranJ Reeve
Jan 30, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J ReeveP F Halloran
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Apr 5, 2014·Journal of the American Society of Nephrology : JASN·Alexandre LoupyPhilip F Halloran
May 11, 2017·International Journal of Technology Assessment in Health Care·Alison ScopeHelen Buckley Woods

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