The 9-O-acetyl GD3 gangliosides are expressed by migrating chains of subventricular zone neurons in vitro

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
L M MiyakoshiC Hedin-Pereira

Abstract

Neurons from the anterior subventricular zone (SVZ) of the cerebral cortex migrate tangentially to become interneurons in the olfactory bulb during development and in adult rodents. This migration was defined as neuronophilic, independent of a radial glial substrate. The cortical SVZ and the rostral migratory stream to the olfactory bulb were shown to be rich in 9-O-acetyl GD3 gangliosides (9-O-acGD3), which have been previously shown to be implicated in gliophilic migration in the rodent cerebral cortex and cerebellum. In the present study, we performed SVZ explant cultures using rats during their first postnatal week to analyze the expression of these gangliosides in chain migration of neuronal precursors. We characterized migrating chains of these neuroblasts through morphological analysis and immunocytochemistry for the neural cell adhesion molecule. By using the Jones monoclonal antibody which binds specifically to 9-O-acGD3 we showed that migrating chains from the SVZ explants express 9-O-acGD3 which is distributed in a punctate manner in individual cells. 9-O-acGD3 is also present in migrating chains that form in the absence of radial glia, typical of the neuronophilic chain migration of the SVZ. Our data indicate that 9...Continue Reading

References

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Citations

Aug 27, 2010·The Journal of Biological Chemistry·Victor Túlio Ribeiro-ResendeFlávio Alves Lara
Aug 21, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Louise MoraesRosalia Mendez-Otero
Jul 1, 2009·Developmental Neurobiology·Mônica MarinsJoão R L Menezes
Jan 16, 2008·Journal of Neurochemistry·Keiko FurukawaKoichi Furukawa
Sep 21, 2011·Molecular and Cellular Neurosciences·L M MiyakoshiC Hedin-Pereira
Nov 19, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J R L MenezesC Hedin-Pereira
Jul 30, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R Mendez-Otero, M F Santiago
Sep 21, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R Mendez-OteroM F Santiago
Apr 23, 2008·Current Protocols in Neuroscience·Dragan Maric, Jeffery L Barker
Oct 1, 2018·Journal of Neurochemistry·Daniele BottaiRiccardo Ghidoni
Jun 2, 2005·Journal of Neuroscience Research·Marcelo F SantiagoRobert K Yu
Nov 3, 2020·Frontiers in Cellular Neuroscience·Michal P JurkowskiJoana Gil-Mohapel

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Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
J R MenezesC Hedin-Pereira
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