The 90K protein increases major histocompatibility complex class I expression and is regulated by hormones, gamma-interferon, and double-strand polynucleotides

Endocrinology
A GrassadoniaLeonard D Kohn

Abstract

Here we report the cloning of the rat 90K, a homolog of the mouse cyclophilin C-associated protein/mouse adherent macrophage and human 90K. The protein is constitutively expressed by FRTL-5 thyrocytes, and its levels are modulated by TSH, insulin/IGF-I, and gamma-interferon. Transfection of the cells with 90K cDNA or exposure to purified 90K resulted in a significant increase of the expression of major histocompatibility complex class I but not class II antigens. An increased expression of 90K was obtained after viral infection or introduction into the cells of fragments of viral, bacterial, or mammalian double-strand polynucleotides. The increase was sequence independent, not CpG mediated, and associated with the expression of molecules characterizing antigen-presenting-cell phenotype. The present data along with results from previous studies suggest that 90K plays an important role in the maintenance of an appropriate level of immune response.

Citations

Nov 22, 2017·Modern Rheumatology·Cristina CecamoreLuciana Breda
Sep 2, 2011·Pharmacological Reviews·Vanesa Gabriela MartínezFrancisco Lozano
Apr 21, 2007·Endocrinology·Antonino GrassadoniaUNKNOWN Consorzio Interuniversitario Nazionale per la Bioncologia
Feb 12, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hiromi UekitaShinji Kihara
Apr 24, 2021·Cell Death Discovery·Antonino GrassadoniaNicola Tinari

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