PMID: 8944759Nov 1, 1996Paper

The A-domain of integrin alpha 2 binds specifically to a range of collagens but is not a general receptor for the collagenous motif

European Journal of Biochemistry
D S TuckwellM J Humphries

Abstract

Integrin alpha 2 beta 1 is a major cellular receptor for collagens, but the molecular basis of its function is unknown. The alpha 2 subunit contains a von Willebrand factor A-domain (I-domain) in its N-terminal region, and it has been demonstrated recently that this domain binds specifically to collagen I. This interaction requires divalent cations (e.g., Mg2+) and native collagen conformation, as does binding of the parent integrin to collagen. The alpha 2 A-domain therefore has a number of functional similarities to the parent integrin, alpha 2 beta 1. However, while sequence specificity has been demonstrated for the parent integrin, no such observations have been made for the A-domain. In particular, it is not known whether the A-domain is responsible for sequence-specific recognition of collagens or whether it binds to the genetic collagenous motif. To investigate the ligand specificity of the alpha 2 A-domain, its binding to a range of collagenous ligands has been studied, with cation dependence, collagen triple-helicity, and inhibition by function-blocking antibodies as criteria for specificity. Binding of the parent integrin was examined for comparison. The alpha 2 A-domain was found to bind specifically to collagens I, ...Continue Reading

References

May 1, 1991·The Journal of Experimental Medicine·F A ChenR B Bankert
Oct 1, 1990·Experimental Cell Research·D GullbergK Rubin
Aug 1, 1986·The Journal of Clinical Investigation·P BockenstedtR I Handin
Oct 1, 1986·The Journal of Cell Biology·M Aumailley, R Timpl
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·T UedaM A Arnaout
Dec 15, 1994·Structure·H J Hoppe, K B Reid
Oct 1, 1993·Critical Reviews in Oncology/hematology·D S Tuckwell, M J Humphries
Mar 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·C DenisD Meyer
Nov 1, 1995·Biochemical Society Transactions·D A CalderwoodM J Humphries

❮ Previous
Next ❯

Citations

Jul 6, 2000·Journal of Biomedical Materials Research·G JohnsonJ G Steele
Jun 22, 1999·Molecular and Biochemical Parasitology·C J McCormickM R Hollingdale
Feb 22, 2002·European Journal of Biochemistry·Alexis AquilinaDanny Tuckwell
Jul 28, 2001·Development, Growth & Differentiation·L G Huggins, W J Lennarz
Dec 29, 2000·Plastic and Reconstructive Surgery·G S ChinM T Longaker
Jun 1, 1997·European Journal of Biochemistry·D DaviesM J Humphries
Dec 3, 1999·European Journal of Clinical Investigation·L Alberio, G L Dale
Sep 4, 2004·The Journal of Biological Chemistry·Pia R-M SiljanderRichard W Farndale
Sep 19, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jyrki Heino
Jun 7, 2006·The Journal of Biological Chemistry·Johannes A EbleSusanne Grässel
Dec 9, 2000·The Journal of Biological Chemistry·M AchisonR W Farndale
Dec 24, 2002·The Journal of Biological Chemistry·Wan-Ming ZhangDonald Gullberg
Sep 24, 2004·The Journal of Biological Chemistry·Jarmo KäpyläJyrki Heino
May 26, 2017·Cellular & Molecular Biology Letters·Edyta WrobelEdyta Brzoska
Mar 6, 2002·Progress in Histochemistry and Cytochemistry·Donald E Gullberg, Evy Lundgren-Akerlund

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.