The A2b adenosine receptor protects against vascular injury

Proceedings of the National Academy of Sciences of the United States of America
Dan YangKatya Ravid

Abstract

The A2b adenosine receptor (A2bAR) is highly abundant in bone marrow macrophages and vascular smooth muscle cells (VSMC). To examine the functional significance of this receptor expression, we applied a femoral artery injury model to A2bAR knockout (KO) mice and showed that the A2bAR prevents vascular lesion formation in an injury model that resembles human restenosis after angioplasty. While considering related mechanisms, we noted higher levels of TNF-alpha, an up-regulator of CXCR4, and of VSMC proliferation in the injured KO mice. In accordance, CXCR4, which is known to attract progenitor cells during tissue regeneration, is up-regulated in lesions of the KO mice. In addition, aortic smooth muscle cells derived from A2bAR KO mice display greater proliferation in comparison with controls. Bone marrow transplantation experiments indicated that the majority of the signal for lesion formation in the null mice originates from bone marrow cells. Thus, this study highlights the significance of the A2bAR in regulating CXCR4 expression in vivo and in protecting against vascular lesion formation.

References

Nov 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J FingerleM A Reidy
May 1, 1993·Genes & Development·V BaldinG Draetta
Dec 31, 1997·Molecular and Cellular Biology·J M ZimmetK Ravid
Dec 10, 1999·The Annals of Thoracic Surgery·J Vinten-JohansenR A Guyton
Jan 21, 2000·Hypertension·R K DubeyE K Jackson
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J W OhE N Benveniste
Apr 3, 2001·Nature Medicine·A SaiuraM Makuuchi
May 23, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·J A McPhersonI J Sarembock
Mar 9, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Geoffrey Burnstock
Jul 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael A ZimmermanAlden H Harken
Apr 1, 2003·Proceedings of the National Academy of Sciences of the United States of America·Noel M CapliceWilliam D Edwards
Apr 26, 2003·Investigative Ophthalmology & Visual Science·Kan KoizumiAntonia M Joussen
Jul 10, 2003·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Adrian R L Gear, David Camerini
Jul 17, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Claudia S HofmannGail E Sonenshein
Jul 20, 2004·Journal of Cellular Biochemistry·Matthew R JonesKatya Ravid
Aug 24, 2004·Circulation Research·Carmen Urbich, Stefanie Dimmeler
Nov 16, 2004·Trends in Cardiovascular Medicine·Chunsheng LiuNoel M Caplice
Feb 11, 2005·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Marco A Q R FortesMiguel Srougi
Jun 1, 2005·Trends in Immunology·Michail V Sitkovsky, Akio Ohta
Feb 24, 2006·Nature Reviews. Cancer·Michael L WhitfieldCharles M Perou
May 23, 2006·Trends in Cardiovascular Medicine·Andreas SchoberChristian Weber
Jul 11, 2006·The Journal of Clinical Investigation·Dan YangKatya Ravid
Aug 2, 2006·Methods in Molecular Biology·Marcin Majka, Mariusz Z Ratajczak
Oct 30, 2007·The Journal of Pharmacology and Experimental Therapeutics·Sergey RyzhovIgor Feoktistov

❮ Previous
Next ❯

Citations

Jan 9, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sean P ColganStefan F Ehrentraut
Apr 13, 2011·Purinergic Signalling·Hillary A Johnston-Cox, Katya Ravid
Aug 2, 2012·Current Atherosclerosis Reports·Milka KoupenovaKatya Ravid
Oct 12, 2010·The Journal of Biological Chemistry·Kengo Moriyama, Michail V Sitkovsky
Mar 10, 2012·The Journal of Biological Chemistry·Shannon H CarrollKatya Ravid
Dec 4, 2010·Antioxidants & Redox Signaling·Almut GrenzHolger K Eltzschig
Apr 10, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bindu P ChandrasekharanShanthi Srinivasan
Mar 15, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Harry Karmouty-QuintanaMichael R Blackburn
Jun 23, 2011·The Journal of Pharmacology and Experimental Therapeutics·Dharini van der HoevenJohn A Auchampach
Dec 3, 2010·American Journal of Physiology. Cell Physiology·Shimin LiJoseph A Bonanno
Jul 4, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rebecca E CagninaJoel Linden
Mar 17, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·György Haskó, Pál Pacher
Dec 7, 2011·Circulation·Milka KoupenovaKatya Ravid
Sep 13, 2008·The Journal of Clinical Investigation·Tobias EckleHolger K Eltzschig
Nov 20, 2009·Cerebrospinal Fluid Research·Jonathan R GenzenAngelique Bordey
Nov 18, 2014·The Journal of Clinical Investigation·Yassine SassiStefan Engelhardt
May 16, 2015·Journal of Cellular Physiology·Anna EisensteinKatya Ravid
May 12, 2009·Trends in Immunology·György HaskóPál Pacher
Sep 4, 2008·Journal of Cellular Physiology·Cynthia St HilaireKatya Ravid
Aug 19, 2010·Journal of Cellular Physiology·Hillary A Johnston-CoxKatya Ravid
Jan 28, 2010·Journal of Thrombosis and Haemostasis : JTH·D YangK Ravid
Jul 6, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Stefania MerighiStefania Gessi
Dec 28, 2010·Biochimica Et Biophysica Acta·Christa E Müller, Kenneth A Jacobson
Sep 14, 2010·Biochimica Et Biophysica Acta·Dovenia S Ponnoth, S Jamal Mustafa
Jun 16, 2010·Biochimica Et Biophysica Acta·Carol M AherneHolger K Eltzschig
Sep 9, 2016·Frontiers in Chemistry·Ying Sun, Pingbo Huang
Aug 26, 2016·Purinergic Signalling·Martha de Oliveira BravoFelipe Saldanha-Araujo
Feb 6, 2017·Molecular Aspects of Medicine·Andrea LeivaLuis Sobrevia
Feb 25, 2017·Journal of Cellular Physiology·Mohammad H KazemiFarhad Jadidi-Niaragh
Mar 17, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Hillary A Johnston-CoxKatya Ravid
Jun 30, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Ilze BotAdriaan P Ijzerman
Sep 27, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Andreas Schober
Jun 14, 2018·American Journal of Physiology. Cell Physiology·Xiaotao XuAizhong Wang
Mar 6, 2013·Journal of Cellular Physiology·Milka Koupenova, Katya Ravid
Sep 11, 2009·Anesthesiology·Holger K Eltzschig
Oct 10, 2009·Physiology·Tobias EckleHolger K Eltzschig
Mar 7, 2012·Expert Review of Clinical Pharmacology·Niels P Riksen, Gerard A Rongen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.