The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease.

Brain : a Journal of Neurology
Shane GrealishLachlan H Thompson

Abstract

Grafts of foetal ventral mesencephalon, used in cell replacement therapy for Parkinson's disease, are known to contain a mix of dopamine neuronal subtypes including the A9 neurons of the substantia nigra and the A10 neurons of the ventral tegmental area. However, the relative importance of these subtypes for functional repair of the brain affected by Parkinson's disease has not been studied thoroughly. Here, we report results from a series of grafting experiments where the anatomical and functional properties of grafts either selectively lacking in A9 neurons, or with a typical A9/A10 composition were compared. The results show that the A9 component of intrastriatal grafts is of critical importance for recovery in tests on motor performance, in a rodent model of Parkinson's disease. Analysis at the histological level indicates that this is likely to be due to the unique ability of A9 neurons to innervate and functionally activate their target structure, the dorsolateral region of the host striatum. The findings highlight dopamine neuronal subtype composition as a potentially important parameter to monitor in order to understand the variable nature of functional outcome better in transplantation studies. Furthermore, the results...Continue Reading

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Citations

Jun 5, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·N Emmanuel Díaz-MartínezIván Velasco
Mar 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Olof TorperMalin Parmar
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Jan 19, 2012·Anatomy & Cell Biology·Jeanne Adiwinata Pawitan

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Methods Mentioned

BETA
dissection

Software Mentioned

Image J
Statistical Package for the Social Sciences
NeuroNE
Imagescope

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