The A930G polymorphism ofP22phox (CYBA) gene but not C242T variation is associated with hypertension: a meta-analysis

PloS One
Yu-Wang QinLian Gu

Abstract

Recently, it has been reported that the A930G and C242T polymorphisms within p22phox (CYBA) gene are involved in the pathogenesis of hypertension. However, the results remain controversial. Furthermore, no previous meta-analysis has been conducted to evaluate the relationship between the A930G and C242T polymorphisms and hypertension. Therefore, we performed this meta-analysis to clarify these controversies. All of the included articles were retrieved from the PubMed and Embase databases, as well as the CNKI, CBM, Chongqing VIP and Wan Fang databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Odds ratios (OR) with corresponding 95% confidence intervals (CI) were used to assess the strength of the association. Accounting for heterogeneity, a fixed or random effects model was respectively adopted. Heterogeneity was checked using the Q test and the I(2) statistic. A cumulative meta-analysis was conducted to estimate the tendency of pooled OR. Funnel plots and Egger's tests were performed to test for possible publication bias. Five articles on A930G with 2003 cases/2434 controls and eight articles on C242T with 2644 cases/1967 controls were identified. A significant associ...Continue Reading

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Citations

Jul 27, 2015·Redox Biology·Sharon O'NeillUlla G Knaus
Feb 7, 2019·The Pharmacogenomics Journal·Santiago CuevasPedro A Jose
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Feb 12, 2020·Journal of Human Hypertension·Monika BuraczynskaWojciech Zaluska
Apr 2, 2021·Circulation Research·Kathy K GriendlingRhian M Touyz

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

Stata

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