The A/A Genotype of XPO1 rs4430924 Is Associated With Higher Risk of Antituberculosis Drug-Induced Hepatotoxicity in Chinese Patients

Journal of Clinical Pharmacology
Xiaomin HeShaowen Tang

Abstract

Antituberculosis (anti-TB) drug-induced hepatotoxicity may be related to the excessive reactive oxygen species induced by hepatotoxic metabolites. Antioxidant activity involves the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. The BTB domain and CNC homologue 1 (Bach1) may compete with Nrf2 for binding to transcriptional enhancers. Elimination of Bach1-mediated transcriptional repression depends on nuclear exporter exportin 1 (Xpo1). Thus, Xpo1 may indirectly affect antioxidant activity. The present study aimed to examine the role of tag single-nucleotide polymorphisms in XPO1 in Chinese anti-TB treatment patients. A 1:2 matched case-control study was conducted using 314 anti-TB drug-induced hepatotoxicity cases and 628 controls. After correcting for weight and hepatoprotectant use, conditional logistic regression analysis showed that patients carrying the AA genotype of rs4430924 in XPO1 were at higher risk of anti-TB drug-induced hepatotoxicity than those carrying the GG genotype based on the subgroup of probable cases (adjusted OR, 1.938; 95%CI, 1.035-3.628; P = .039), and marginally significant differences were also found under the recessive model (P = .048) and the additive model (P = .047). Based o...Continue Reading

References

Nov 15, 2000·Lancet·S R KnowlesN H Shear
Jun 4, 2004·The EMBO Journal·Hiroshi SuzukiKazuhiko Igarashi
Sep 14, 2006·Annual Review of Pharmacology and Toxicology·Thomas W KenslerShyam Biswal
Nov 13, 2007·Journal of Gastroenterology and Hepatology·Alma TostmannRichard Dekhuijzen
Feb 29, 2008·Pharmacogenomics·Puspita Das RoyBidyut Roy
May 22, 2010·Lancet·Knut LönnrothMario C Raviglione
Oct 27, 2011·Journal of Signal Transduction·Mohamed Kodiha, Ursula Stochaj
Nov 28, 2012·Communicative & Integrative Biology·Jie LiKazuhiko Igarashi
Apr 2, 2014·Nature Genetics·De-Chen LinH Phillip Koeffler
May 6, 2014·Seminars in Cancer Biology·Asfar S Azmi
Jun 1, 2014·Seminars in Liver Disease·Thomas J UrbanGuruprasad P Aithal
Feb 6, 2015·International Journal of Molecular Sciences·Victoria E Villegas, Peter G Zaphiropoulos
Feb 20, 2015·Archives of Toxicology·Ru ChenSiyan Zhan
Mar 1, 2013·Journal of Clinical and Experimental Hepatology·Vidyasagar Ramappa, Guruprasad P Aithal
Dec 30, 2015·International Journal of Molecular Sciences·Gaby Danan, Rolf Teschke
Jul 18, 2017·Anatomy & Cell Biology·Yun Hak KimSae-Ock Oh
Jan 3, 2018·European Journal of Gastroenterology & Hepatology·Cvetka Pernat DrobežUroš Potočnik
Mar 3, 2018·Biochimica Et Biophysica Acta. Molecular Cell Research·Ilaria BellezzaRosario Donato
May 23, 2018·Antimicrobial Agents and Chemotherapy·Wing Wai YewDenise P Chan
Sep 19, 2018·The Lancet Global Health· The Lancet Global Health
Oct 15, 2018·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Haiping ZhangShaowen Tang
Nov 14, 2018·The Lancet Global Health· The Lancet Global Health

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