The ABC-transporter AtmA is involved in nickel and cobalt resistance of Cupriavidus metallidurans strain CH34

Antonie van Leeuwenhoek
André Mikolay, Dietrich H Nies

Abstract

Cupriavidus metallidurans CH34 genome contains an ortholog of Atm1p named AtmA (Rmet_0391, YP_582546). In Saccharomyces cerevisiae, the ABC-type transport system Atm1p is involved in export of iron-sulfur clusters from mitochondria into the cytoplasm for assembly of cytoplasmic iron-sulfur containing proteins. An atmA mutant of C. metallidurans was sensitive to nickel and cobalt but not iron cations. AtmA increased also resistance to these cations in Escherichia coli strains that carry deletions of the genes for other nickel and cobalt transport systems. In C. metallidurans, atmA expression was not significantly induced by nickel and cobalt, but repressed by zinc. AtmA was purified as a 70 kDa protein after expression in E. coli. ATPase activity of AtmA was stimulated by nickel and cobalt.

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Citations

Nov 3, 2015·Gene·Marek GadzalskiPaweł Stączek
Jul 19, 2012·Proteins·Wenlin LiNick V Grishin
Apr 12, 2016·Metallomics : Integrated Biometal Science·Dietrich H Nies
Jan 31, 2014·Journal of Environmental Health Science & Engineering·Hoda AlboghobeishMonir Doudi
Nov 1, 2015·Biochemical Society Transactions·Theresia A SchaedlerJanneke Balk
Oct 28, 2021·PeerJ·Veronika PishchikDebasis Chakrabarty

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