The aberrant retino-retinal projection during optic nerve regeneration in the frog. I. Time course of formation and cells of origin

The Journal of Comparative Neurology
R C Bohn, D J Stelzner

Abstract

We have reported previously that during optic nerve regeneration in Rana pipiens, axons are misrouted into the opposite nerve and retina. In the present investigation we have examined the time course of formation of these "misrouted" axons and their cells of origin. The right eye of 31 frogs was injected with 3H-proline at various times after right optic nerve crush. In every frog examined 2 weeks and later after nerve crush, the distribution of autoradiographic label indicated that axons from the right eye had grown into the left optic nerve at the chiasm. The amount of label increased from 2 weeks to reach a maximum at 6 weeks where the entire left nerve was filled with silver grains. At 5 to 6 weeks after crush, labeled axons were found within the ganglion cell fiber layer (GCFL) of the retina of the opposite eye for a maximum distance of 2.3 mm from the optic disc. In frogs examined at intervals later than 6 weeks after crush, the amount of label within the left eye and nerve progressively decreased, indicating a gradual disappearance of the misrouted axons. Studies using anterograde transport of horseradish peroxidase (HRP) after nerve injection confirmed these autoradiographic findings. The position of ganglion cells in t...Continue Reading

References

Feb 1, 1978·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M M Mesulam
Jan 1, 1978·The Journal of Physiology·M J Dennis, J W Yip
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D G PuroM Nirenberg
Apr 1, 1979·The Anatomical Record·S Goldberg, B Frank
Feb 1, 1978·Experimental Cell Research·G A Dunn, T Ebendal
Jul 15, 1978·The Journal of Comparative Neurology·R H Nordlander, M Singer
Feb 1, 1979·The Journal of Comparative Neurology·D H Beach, M Jacobson
Mar 15, 1977·Experimental Cell Research·T Ebendal, C O Jacobson
Jul 15, 1976·The Journal of Comparative Neurology·M Murray
Sep 1, 1975·Developmental Biology·J Currie, W M Cowan
Nov 1, 1976·The Journal of Comparative Neurology·M Constantine-Paton, R R Capranica
Apr 15, 1975·The Journal of Comparative Neurology·V Hamburger
May 1, 1975·Developmental Biology·P C Letourneau
May 1, 1975·Developmental Biology·P C Letourneau
Oct 15, 1974·The Journal of Comparative Neurology·R F Fangboner, J W Vanable
Dec 1, 1974·The Journal of Experimental Zoology·J E Turner, M Singer
Apr 5, 1972·Nature: New Biology·R M GazeM J Keating
Nov 1, 1972·Experimental Neurology·M Egar, M Singer
Dec 1, 1971·The Journal of Comparative Neurology·G A Dunn
May 1, 1958·The American Journal of Anatomy·V HAMBURGER
Jan 1, 1960·International Review of Neurobiology·R M GAZE
Jan 1, 1963·Experimental Neurology·D G ATTARDI, R W SPERRY
Oct 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·R W SPERRY
Jan 1, 1978·Neuroscience Letters·J Glastonbury, K Straznicky
Jun 1, 1946·Journal of Cellular Physiology·G MARSH, H W BEAMS

❮ Previous
Next ❯

Citations

Aug 1, 1984·Journal of Neurocytology·S S Scherer, S S Easter
Apr 1, 1990·Journal of Neurocytology·F J Liuzzi, R H Miller
Dec 1, 1986·Neurochemical Pathology·D J StelznerJ A Strauss
Nov 1, 1984·Brain Research·S M Bunt, P Fill-Moebs
May 1, 1986·Brain Research·J C Presson, R D Fernald
Sep 25, 1989·Neuroscience Letters·P Tóth, C Straznicky
Feb 24, 2015·Neuroscience Letters·Vanessa K Avellaneda-ChevrierBalwantray C Chauhan
Mar 24, 2015·Experimental Eye Research·F M Nadal-NicolásM Agudo-Barriuso
Jan 6, 1997·The Journal of Comparative Neurology·L D BeazleyS A Dunlop
Oct 15, 1992·The Journal of Comparative Neurology·F Scalia
Jun 15, 1985·The Journal of Comparative Neurology·M F Humphrey, L D Beazley
Jan 1, 1985·Journal of Neuroscience Research·W A HarrisN Gallenson
Jan 15, 1985·The Journal of Comparative Neurology·F Scalia, D E Matsumoto
Aug 10, 1983·The Journal of Comparative Neurology·T A RehM Constantine-Paton
Dec 20, 1983·The Journal of Comparative Neurology·D R Bernstein, D J Stelzner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.