The aberrant retino-retinal projection during optic nerve regeneration in the frog. II. Anterograde labeling with horseradish peroxidase

The Journal of Comparative Neurology
R C Bohn, D J Stelzner

Abstract

Previous experiments have shown that a substantial number of regenerating optic axons in adult frogs (Rana pipiens) are misrouted into the opposite optic nerve and retina during early stages of regeneration. This projection is maximal at 5 and 6 weeks after optic nerve crush. To further characterize this anomalous projection, small quantities of horseradish peroxidase (HRP) were injected into the right eye or right optic nerve 5 or 6 weeks after right optic nerve crush. Twenty-four hours later the animals were killed and regenerating axons anterogradely filled with HRP were reacted with the tetramethyl-benzidine method or a diaminobenzidine-CoCl2 method. Serial reconstruction tracing the course of individual axons through the optic chiasm showed that few of the axons projecting into the opposite optic nerve were collaterals of axons projecting centrally. Instead, the majority of labeled axons misdirected into the opposite nerve or contributing to an expanded projection into the ipsilateral optic tract turned out of the chiasm without branching. Many of the labeled regenerating axons had unusual trajectories within the chiasm, making abrupt turns or changing their direction of growth. Most of the axons misrouted into the opposit...Continue Reading

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Citations

Dec 1, 1986·Neurochemical Pathology·D J StelznerJ A Strauss
Feb 24, 2015·Neuroscience Letters·Vanessa K Avellaneda-ChevrierBalwantray C Chauhan
Mar 24, 2015·Experimental Eye Research·F M Nadal-NicolásM Agudo-Barriuso
Sep 16, 2004·The Journal of Comparative Neurology·Sarah A DunlopLyn D Beazley
Jan 6, 1997·The Journal of Comparative Neurology·L D BeazleyS A Dunlop
Mar 18, 2016·Journal of Neurophysiology·Xiaolan TangChristopher L Passaglia
Dec 9, 2020·Development·Shane D'Souza, Richard A Lang

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