The aberrant retino-retinal projection during optic nerve regeneration in the frog. III. Effects of crushing both nerves

The Journal of Comparative Neurology
R C Bohn, D J Stelzner

Abstract

Previous reports from this laboratory have shown that a substantial number of optic axons are misrouted after optic nerve regeneration in the adult frog, Rana pipiens. Regenerating axons from a crushed optic nerve are distributed throughout the opposite nerve. In this study, we report the effect of crushing both optic nerves (double crush) on the pattern and degree of axonal misrouting. In 28 frogs both optic nerves were crushed at the same time (simultaneous double crush) and animals survived for varying periods before the right eye was injected with 3H-proline and the brain processed for autoradiography 24 hours later. In every frog with postoperative survivals longer than 2 weeks, labeled axons from the right eye were found in the left optic nerve. However, when compared to the amount of label seen in frogs in which only the right optic nerve was crushed (single crush) there was substantially less label within the left nerve of frogs after crushing both nerves. Label was also found only at the edge of the left nerve in material from double crush frogs, unlike that found after single crush. In four of six frogs where the left nerve was crushed 1 week after the right nerve (delayed double crush), the proximal end of the left n...Continue Reading

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Citations

Jan 1, 1989·Experimental Brain Research·T Nakayama, S Furuya
Dec 1, 1986·Neurochemical Pathology·D J StelznerJ A Strauss
Feb 24, 2015·Neuroscience Letters·Vanessa K Avellaneda-ChevrierBalwantray C Chauhan
Mar 24, 2015·Experimental Eye Research·F M Nadal-NicolásM Agudo-Barriuso
Jan 6, 1997·The Journal of Comparative Neurology·L D BeazleyS A Dunlop
Dec 20, 1983·The Journal of Comparative Neurology·D R Bernstein, D J Stelzner

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