PMID: 8469425Feb 19, 1993Paper

The ability of humans to localise noxious stimuli

Neuroscience Letters
M KoltzenburgH E Torebjörk

Abstract

We have investigated the ability of humans to localise noxious stimuli on the dorsum of the hand. Pin-prick (non-penetrating needle prick), noxious heat (round 1 cm2 copper probe heated to 50 degrees C), mustard oil (100% applied topically in a small cotton ball, diameter 5 mm) and histamine (iontophoresis of 20 mC delivered to an area of 75 mm2) were applied to skin with intact innervation and during a differential nerve compression block of the superficial radial nerve when only C-fibres were conducting. The mean mislocalisation (+/- S.E.M.; n = 8) of all stimuli was 9.5 +/- 0.8 mm with normal nerve conduction and 8.9 +/- 1.2 during the differential nerve block. There was no significant difference between the noxious submodalities. By contrast, when nerve conduction was intact, purely tactile stimulation (7 mN von Frey hair) was significantly better localised having a mean error of 5.5 +/- 0.4 mm. We conclude that focal stimuli evoking itch or pain can be localised with high precision which is only marginally worse than for tactile stimuli. This suggests the existence of a somatotopical representation for noxious inputs in the brain similar to that found for tactile stimuli.

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Citations

Apr 8, 2009·Experimental Brain Research·Barbara Namer, Hermann Otto Handwerker
Jul 7, 1995·Neuroscience Letters·C E Moore, W Schady
Feb 19, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Shigeki OmoriRyusuke Kakigi
Mar 13, 1999·Annual Review of Psychology·J C Craig, G B Rollman
Jun 20, 2008·Journal of Neurophysiology·Barbara NamerMatthias Ringkamp
Jul 7, 2009·Neuroscience Letters·H O Handwerker
Dec 1, 1995·Seminars in Dermatology·A Ekblom
May 26, 2012·The European Journal of Neuroscience·Tasuku AkiyamaEarl E Carstens
Feb 23, 2013·Current Biology : CB·Patrick HaggardMatthew R Longo
Dec 23, 2008·Neuropsychologia·Liana E BrownMelvyn A Goodale
Mar 6, 1999·Pain·R D TreedeA K Jones
Feb 15, 2017·Pain·Alexandre S QuevedoRobert C Coghill
Jun 23, 2006·Nature Reviews. Neuroscience·Akihiko IkomaMartin Schmelz
Jul 25, 2006·Pain·Ruth DefrinGideon Urca
Jun 5, 2014·The Journal of Pharmacology and Experimental Therapeutics·Ki Jeong LeeNarender R Gavva
Dec 17, 2017·The European Journal of Neuroscience·Tatjana I KichkoPeter W Reeh
Nov 8, 2017·Pain·Ken Steffen FrahmOle Kæseler Andersen
Jan 1, 1997·Anesthesia and Analgesia·S S Liu, P D Ware
Nov 14, 1997·Journal of Neurophysiology·R SchmidtH E Torebjörk
Oct 5, 2002·Journal of Neurophysiology·R SchmidtH E Torebjörk
Oct 8, 2019·Antioxidants & Redox Signaling·Alma MartelliVincenzo Calderone

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