The Ability of Quantitative, Specific, and Sensitive Point-of-Care/Chair-Side Oral Fluid Immunotests for aMMP-8 to Detect Periodontal and Peri-Implant Diseases

Disease Markers
Saeed AlassiriTimo Sorsa

Abstract

The analysis of the disease-specific oral and systemic biomarkers in saliva and oral fluids (i.e., mouth rinse, gingival crevicular fluid (GCF), and peri-implantitis fluid (PISF)) is demanding. Several hosts and microbial factors may influence their expression, release, and levels. The type of saliva/oral fluids utilized for the diagnostics affects the analysis. High sensitivity and specificities together with sophisticated methods and techniques are essential for valuable outcome. We describe here recently developed practical, convenient, inexpensive, noninvasive, and quantitative mouth rinse and PISF/GCF/chair-side/point-of-care (PoC) lateral-flow aMMP-8 immunoassays (PerioSafe and ImplantSafe/ORALyser) to detect, predict, and monitor successfully the course, treatment, and prevention of periodontitis and peri-implantitis, respectively. The tests have been independently and successfully validated to differentiate periodontal and peri-implant health and disease in Finland, Germany, Netherland, Sweden, Turkey, Nigeria, Malawi, and USA. The clinical use of salivary/oral fluid biomarkers to identify oral and systemic conditions requires additional studies utilizing these noninvasive screening, diagnostic, and preventive aMMP-8 Po...Continue Reading

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Citations

Dec 29, 2018·Journal of Clinical Periodontology·Sandeep KarnaHyun-Duck Kim
Apr 9, 2019·Acta Odontologica Scandinavica·Xiaohong YuYan Pan
Jul 20, 2019·Journal of Periodontal Research·Ishita BhavsarMohanad Al-Sabbagh
Oct 15, 2019·Journal of Periodontal Research·Dimitrios NalmpantisDimitra Sakellari
May 17, 2019·Clinical Oral Investigations·Gerd-Jan BoelenGhislain Opdenakker
Dec 19, 2019·Periodontology 2000·Lorne M Golub, Hsi-Ming Lee
Aug 9, 2019·Journal of Periodontology·Nicole B ArweilerThorsten M Auschill
Aug 14, 2020·Journal of Periodontal Research·Zeynep Pinar Keles YucelTimo Sorsa
Oct 12, 2018·International Journal of Dentistry·Ahmed Al-MajidTimo Sorsa
Dec 11, 2020·Clinical and Experimental Dental Research·Andreas GrigoriadisDimitra Sakellari
Feb 11, 2021·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Annika NorrmanJaana Helenius-Hietala
Dec 10, 2020·International Journal of Environmental Research and Public Health·Luciene Cristina FigueiredoTamires Szeremeske Miranda
May 19, 2021·BMC Oral Health·Yong ZhangYu Cai
Jul 2, 2021·The Saudi Dental Journal·Jennifer Orozco-PáezDarío Méndez-Cuadro
Aug 28, 2021·Clinical and Experimental Dental Research·Matti MauramoTuomas Waltimo
Sep 2, 2021·Expert Review of Proteomics·Timo SorsaKrishan Gauba

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Software Mentioned

PerioSafe
ORALyser
ImplantSafe

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