Abstract
The analysis of the disease-specific oral and systemic biomarkers in saliva and oral fluids (i.e., mouth rinse, gingival crevicular fluid (GCF), and peri-implantitis fluid (PISF)) is demanding. Several hosts and microbial factors may influence their expression, release, and levels. The type of saliva/oral fluids utilized for the diagnostics affects the analysis. High sensitivity and specificities together with sophisticated methods and techniques are essential for valuable outcome. We describe here recently developed practical, convenient, inexpensive, noninvasive, and quantitative mouth rinse and PISF/GCF/chair-side/point-of-care (PoC) lateral-flow aMMP-8 immunoassays (PerioSafe and ImplantSafe/ORALyser) to detect, predict, and monitor successfully the course, treatment, and prevention of periodontitis and peri-implantitis, respectively. The tests have been independently and successfully validated to differentiate periodontal and peri-implant health and disease in Finland, Germany, Netherland, Sweden, Turkey, Nigeria, Malawi, and USA. The clinical use of salivary/oral fluid biomarkers to identify oral and systemic conditions requires additional studies utilizing these noninvasive screening, diagnostic, and preventive aMMP-8 Po...Continue Reading
References
Jul 1, 1986·Journal of Clinical Periodontology·N P LangB E Siegrist
Jan 1, 1995·Journal of Periodontal Research·W LeeC A McCulloch
Aug 22, 1997·The Journal of Biological Chemistry·T SorsaU H Stenman
May 4, 1999·Infection and Immunity·R RomanelliC A McCulloch
May 25, 1999·Periodontology 2000·A Mombelli, N P Lang
Dec 10, 1999·Journal of Periodontology·S ManciniC A McCulloch
Jun 28, 2003·Journal of Periodontal Research·Päivi MäntyläTimo Sorsa
Aug 18, 2004·Journal of Clinical Periodontology·P AxelssonJ Lindhe
Mar 22, 2007·Proceedings of the National Academy of Sciences of the United States of America·Amy E HerrAnup K Singh
Apr 22, 2010·Mycoses·Pirjo PärnänenTimo Sorsa
Apr 23, 2013·Journal of Periodontology·S O NwhatorD O Opedun
May 11, 2013·Journal of Periodontology·Jussi M LeppilahtiPäivi Mäntylä
Apr 7, 2015·Medical Microbiology and Immunology·Susan Izadi BorujeniPeter Eickholz
Feb 18, 2016·PloS One·Thierry PrazuckGilles Pialoux
Mar 17, 2016·Acute Cardiac Care·Mikko T NieminenTimo Sorsa
May 24, 2016·Journal of Periodontal Research·K LorenzT Hoffmann
Jun 9, 2016·Oral Diseases·N JohnsonC S Miller
Dec 19, 2016·Journal of Periodontology·Anna Maria HeikkinenTimo Sorsa
Feb 9, 2017·Disease Markers·Tarja MynttiVedran Stefanovic
Feb 10, 2017·Journal of Dental Research·N M O'Brien-SimpsonE C Reynolds
Mar 10, 2017·Diagnostic Microbiology and Infectious Disease·Dirk ZiebolzSven Rinke
Aug 15, 2017·Nature Reviews. Disease Primers·Denis F KinanePanos N Papapanou
Aug 16, 2017·Nature Communications·J RitzerL Meinel
Aug 24, 2017·BMC Women's Health·Tara ShochetPaul D Blumenthal
Sep 7, 2017·Journal of Periodontology·Jun-Ichi KidoToshihiko Nagata
Sep 13, 2017·Journal of Periodontal Research·E F de MoraisR A Freitas
Sep 15, 2017·Nature Reviews. Disease Primers·Timo SorsaMarcela Hernández
Nov 18, 2017·British Journal of Cancer·Mikko T NieminenTimo Sorsa
Dec 19, 2017·Archives of Oral Biology·Everton Freitas de de MoraisRoseana de Almeida Freitas
Citations
Dec 29, 2018·Journal of Clinical Periodontology·Sandeep KarnaHyun-Duck Kim
Jan 8, 2019·Oral Diseases·Courtney P RudickTakanari Miyamoto
Mar 27, 2019·Diagnostics·Ismo T RäisänenAnna Maria Heikkinen
Apr 9, 2019·Acta Odontologica Scandinavica·Xiaohong YuYan Pan
Jun 25, 2019·Journal of Dental Research·S O NwhatorT Sorsa
Jul 20, 2019·Journal of Periodontal Research·Ishita BhavsarMohanad Al-Sabbagh
Oct 15, 2019·Journal of Periodontal Research·Dimitrios NalmpantisDimitra Sakellari
Sep 11, 2019·Microorganisms·Pirjo PärnänenTimo Sorsa
May 17, 2019·Clinical Oral Investigations·Gerd-Jan BoelenGhislain Opdenakker
Dec 19, 2019·Periodontology 2000·Lorne M Golub, Hsi-Ming Lee
Aug 9, 2019·Journal of Periodontology·Nicole B ArweilerThorsten M Auschill
Jul 26, 2019·Journal of Periodontology·Ismo T RäisänenTimo Sorsa
Aug 10, 2019·Journal of Periodontology·Wei HuangRuo-Pan Huang
Mar 22, 2020·Journal of Clinical Periodontology·Nora Arias-BujandaInmaculada Tomás
Aug 14, 2020·Journal of Periodontal Research·Zeynep Pinar Keles YucelTimo Sorsa
Aug 14, 2020·Journal of Periodontology·Alejandra ChaparroSebastián E Illanes
Oct 27, 2018·Diagnostics·Ismo T RäisänenTimo Sorsa
Dec 11, 2019·Diagnostics·Hatem AlassyLarry Wolff
Oct 12, 2018·International Journal of Dentistry·Ahmed Al-MajidTimo Sorsa
Jan 26, 2020·Diagnostics·Timo SorsaDimitra Sakellari
Jun 20, 2019·Odontology·Norma Samanta Romero-CastroNatividad Castro-Alarcón
Oct 20, 2019·Diagnostics·Andreas GrigoriadisDimitra Sakellari
Aug 6, 2019·Frontiers in Immunology·Carla AlvarezAlpdogan Kantarci
Apr 30, 2020·Biosensors·Timo SorsaIsmo T Räisänen
Aug 9, 2020·Diagnostics·Hanna LähteenmäkiTimo Sorsa
Aug 1, 2019·Scientific Reports·John J TaylorPhilip M Preshaw
Sep 19, 2018·Diagnostics·Jussi M LeppilahtiTimo Sorsa
Oct 18, 2020·Diagnostics·Jungwon LeeEunkyung Kim
Oct 22, 2020·Diagnostics·Sarhang S GulAndrew Rawlinson
Aug 26, 2020·Journal of Clinical Periodontology·Hyun-Duck KimByungGee Kim
Dec 10, 2020·Diagnostics·Lorne M GolubPhilip M Preshaw
Dec 11, 2020·Clinical and Experimental Dental Research·Andreas GrigoriadisDimitra Sakellari
Dec 12, 2020·Journal of Periodontal Research·Ismo T RäisänenAnna Maria Heikkinen
Jan 8, 2021·Expert Review of Proteomics·Mutlu KeskinTimo Sorsa
Feb 11, 2021·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Annika NorrmanJaana Helenius-Hietala
Feb 9, 2021·Archives of Oral Biology·V Özgen ÖztürkSaeed Alassiri
Dec 10, 2020·International Journal of Environmental Research and Public Health·Luciene Cristina FigueiredoTamires Szeremeske Miranda
May 1, 2021·Diagnostics·Ismo T RäisänenTimo Sorsa
May 19, 2021·BMC Oral Health·Yong ZhangYu Cai
Jul 2, 2021·The Saudi Dental Journal·Jennifer Orozco-PáezDarío Méndez-Cuadro
Aug 3, 2021·International Journal of Biological Macromolecules·Fan ZhangChangchang Ye
Jul 28, 2021·Journal of Clinical Periodontology·Timo SorsaIsmo T Räisänen
Aug 18, 2021·Oral Diseases·Shipra GuptaTimo Sorsa
Aug 28, 2021·Clinical and Experimental Dental Research·Matti MauramoTuomas Waltimo
Sep 2, 2021·Expert Review of Proteomics·Timo SorsaKrishan Gauba