The ability of selected pyridinium salts to increase the cytotoxic activity of vincristine but not doxorubicin towards sensitive and multidrug resistant promyelocytic leukaemia HL60 cells

The Journal of Pharmacy and Pharmacology
Agnieszka MaruszewskaJolanta Tarasiuk

Abstract

The aim of this study was to examine the effect of selected pyridinium salts, 1-methyl-3-nitropyridine chloride (MNP(+)Cl(-)) and 3,3,6,6,10-pentamethyl-3,4,6,7-tetrahydro-[1,8(2H,5H)-dion]acridine chloride (MDION(+)Cl(-)), on the activity of doxorubicin (DOX) and vincristine (VINC) towards human promyelocytic leukaemia HL60 cells as well as its multidrug resistant (MDR) sublines exhibiting two different phenotypes of MDR related to the overexpression of P-glycoprotein (HL60/VINC) or MRP1 (HL60/DOX). MNP and MDION salts were much less cytotoxic themselves (about 100-fold and 2000-fold compared with DOX and VINC, respectively) against HL60 cells but, in contrast to DOX and VINC, they conserved an important cytotoxic activity towards resistant HL60/VINC and HL60/DOX cells (resistance factor, RF = 2-4.5). It was shown that MNP(+)Cl(-) and MDION(+)Cl(-) increased the cytotoxicity of non-bioreductive antitumour agent VINC towards human promyelocytic leukaemia HL60 cells and its resistant sublines HL60/VINC and HL60/DOX. However, in the case of DOX the decrease in its cytotoxic activity towards all studied cell lines was observed in the presence of MNP(+)Cl(-) and MDION(+)Cl(-). Presented data suggest that the bioreductive drug DOX, ...Continue Reading

References

Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·G J ZamanH J Broxterman
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·G C SmithC R Wolf
Apr 21, 1993·Journal of the National Cancer Institute·P M Chaudhary, I B Roninson
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·S PaulG D Kruh
Feb 11, 1999·Bioscience, Biotechnology, and Biochemistry·S OgataH Taguchi
Mar 29, 2000·Bioscience, Biotechnology, and Biochemistry·S OgataH Taguchi
Aug 17, 2000·Journal of the National Cancer Institute·P BorstJ Wijnholds
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Z X LiuG Dennert
Jan 25, 2002·IUBMB Life·A MordenteG Minotti
Jan 31, 2002·Annual Review of Medicine·Michael M Gottesman
May 15, 2002·Bioscience, Biotechnology, and Biochemistry·Shin OgataHiroshi Taguchi
Jul 19, 2002·Chemical Communications : Chem Comm·Rodolfo LavillaAlessandro Spada
Oct 9, 2002·Current Protein & Peptide Science·Karin F K Ejendal, Christine A Hrycyna
Feb 5, 2003·Drug Discovery Today·Marek LosAndrzej Mackiewicz
Mar 22, 2003·Current Opinion in Cell Biology·Su-Ju Lin, Leonard Guarente
Apr 8, 2003·Current Medicinal Chemistry. Anti-cancer Agents·M A Jordan
Jul 23, 2003·Trends in Pharmacological Sciences·Paula M ChecchiHarish C Joshi
Dec 12, 2003·Clinical Breast Cancer·Edgardo Rivera
Jan 6, 2004·Free Radical Research·Marzena WieczorkowskaJerzy Gebicki
Jul 6, 2004·Journal of Ethnopharmacology·Celia AbajoMaría Pilar Vinardell
Oct 8, 2004·Journal of Biochemistry and Molecular Biology·Robert Antoni OlekJedrzej Antosiewicz
Jan 11, 2005·The Journal of Pathology·D B Longley, P G Johnston
Mar 7, 2006·Nature Reviews. Drug Discovery·Gergely SzakácsMichael M Gottesman

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Citations

May 8, 2010·European Journal of Pharmacology·Robert NowakJolanta Tarasiuk

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