The ability of the aryl hydrocarbon receptor to regulate ovarian follicle growth and estradiol biosynthesis in mice depends on stage of sexual maturity.

Biology of Reproduction
Isabel Hernandez-OchoaJodi A Flaws

Abstract

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxicity of environmental chemicals and regulates many physiological functions, including processes in female reproduction. Previous studies demonstrated that Ahr deletion leads to slow ovarian follicle growth because of impaired estradiol production and reduced gonadotropin responsiveness in prepubertal mice. These studies, however, did not determine how Ahr deletion impairs estradiol production or whether the effects of Ahr deletion on follicle growth and estradiol production persist in adulthood. Thus, the present study evaluated the effect of Ahr deletion on steroid precursors in the estradiol biosynthesis pathway. Furthermore, this study evaluated follicle growth and estradiol biosynthesis in wild-type (WT) and Ahr knockout (AhrKO) antral follicles at different stages of sexual maturity. AhrKO antral follicles from prepubertal mice had slower growth, produced lower estradiol levels, and had reduced cyclin D2 (Ccnd2) expression compared to WT follicles. AhrKO follicles from adult mice, however, produced higher androgen levels and expressed higher levels of Ccnd2 compared to WT follicles. Furthermore, AhrKO follicles from adult m...Continue Reading

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Citations

Oct 20, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jackye PeretzJodi A Flaws
Apr 4, 2013·Reproductive Biology and Endocrinology : RB&E·Isabel Hernández-OchoaJodi A Flaws
Feb 15, 2011·The Journal of Veterinary Medical Science·Yosuke SakuradaKinji Shirota
Aug 25, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Zelieann R CraigJodi A Flaws
Oct 24, 2015·Toxicology and Applied Pharmacology·Teresita Rocio Moore-AmbrizIsabel Hernández-Ochoa
Apr 30, 2015·Archives of Gynecology and Obstetrics·Vincenza SofoMauricio Simões Abrão
Jan 26, 2011·Toxicology and Applied Pharmacology·Karina A BarreiroAlicia G Faletti
May 11, 2016·Toxicology·Eric Alejandro Rhon-CalderónAlicia Graciela Faletti
Sep 5, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Isabel Bravo-FerrerMaría A Moro
May 12, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·Jan NevoralMilena Králíčková
Jun 20, 2019·International Journal of Molecular Sciences·Eileen DeusterBastian Czogalla
Oct 31, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Youn Kyung ChungYoung Min Choi
Jan 6, 2021·International Journal of Molecular Sciences·Eva SernaJose Vina
Feb 15, 2021·Reproductive Biology and Endocrinology : RB&E·Yunyao LuoLiangzhi Xu

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Methods Mentioned

BETA
PCR
ELISA
immunoprecipitation

Software Mentioned

SAS
qPCR
ImageJ
GraphPad Prism
GraphPad

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