The ability of three global plasma assays to recognize thrombophilia

Thrombosis Research
Marianne S AndresenLien My Diep

Abstract

Three global assays, the Calibrated Automated Thrombogram (CAT), the ProC Global (PCG), and the Coagulation Inhibitor Potential (CIP) were performed in frozen plasma samples from 24 normal controls and 24 patients with inherited thrombophilia. Six patients had inherited antithrombin (AT) deficiency; 18 patients had abnormalities in the protein C/S anticoagulant system (protein C deficiency (n=3), protein S deficiency (n=10), homozygous FV Leiden mutation (n=5)). Nine of these twenty four patients carried additionally the heterozygous FV Leiden mutation. All three assays separated the thrombophilia group and the control group (P=0.083 for CAT, P<0.0001 for the other two assays) but there was considerable overlap, particularly in the CAT assay. The CAT assay separated all plasma samples with AT deficiency but was less sensitive to abnormalities in the protein C/S system. In contrast, ProC Global was more sensitive to abnormalities in the protein C system than to AT deficiency. The CIP assay was approximately equally sensitive to defects in both systems. Receiver operator characteristic (ROC) curves confirmed that the ProC Global and the CIP assays performed better than the CAT assay (P=0.0179 and P=0.0003, respectively). With the...Continue Reading

References

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Citations

Aug 24, 2005·British Journal of Haematology·Trevor Baglin
Oct 13, 2005·Haemophilia : the Official Journal of the World Federation of Hemophilia·B Sørensen, J Ingerslev
Jun 20, 2008·British Journal of Haematology·J J van VeenM Makris
Mar 29, 2005·Thrombosis Research·Marianne S Andresen, Ulrich Abildgaard
May 22, 2018·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Barbara RégerOrsolya Tóth
Jun 22, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Marianne S AndresenPer Morten Sandset
Mar 17, 2021·Thrombosis Research·Natalie SmithMarilyn Manco-Johnson

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