PMID: 3768725Oct 1, 1986Paper

The abnormal development of the gracile nucleus in the neurological mutant rat mf

Brain Research
L Chimelli, Francesco Scaravilli

Abstract

A morphological and quantitative study was carried out of the prenatal and early postnatal development of the gracile nucleus in the mutant rat 'mutilated foot' (mf), which is affected by a sensory neuropathy inherited by autosomal recessive transmission. Microscopic examination showed that the nucleus of both normal and mf rats become morphologically identifiable at embryonic day 19 and that its appearance was comparable in the two groups of rats up to postnatal day 2. Subsequently the nucleus in the mutants appeared smaller than in control rats and the number of nerve cells in it decreased dramatically. Glomeruli, the type of synapses known to be formed between primary sensory ascending fibres and dendrites of gracile nerve cells, were observed in the mf rat, but were greatly reduced in number and in size compared with those in normal littermates. Reconstruction of nerve cell volumes showed that, in mf rats, volumes increased considerably less than in controls. These results suggest that the abnormalities observed in the gracile nucleus of mf rats are secondary to the decreased number of afferent fibres originating from the dorsal root ganglia and represent a form of 'anterograde transneuronal degeneration'. In the mutant thi...Continue Reading

References

Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·P G Clarke, W M Cowan
Feb 15, 1973·The Journal of Comparative Neurology·A D Loewy
Nov 1, 1973·The Anatomical Record·R L Gulley
Mar 24, 1972·Brain Research·J I JohnsonP Ulindki
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J W FawcettW M Cowan
Aug 10, 1983·The Journal of Comparative Neurology·M R BennettI Hutchinson
Jan 1, 1981·Experimental Brain Research·W SchultzM Wiesendanger
Jun 10, 1981·The Journal of Comparative Neurology·D S RootmanM Hay

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