The abnormal expression of retinoic acid receptor-beta, p 53 and Ki67 protein in normal, premalignant and malignant esophageal tissues

World Journal of Gastroenterology : WJG
Min XuWei Zhang

Abstract

Esophageal cancer remains a significant health problem worldwide. It is important to investigate alterations in expression of retinoic acid receptor-beta, p 53 and Ki67 proteins in esophageal carcinogenesis. To find biomarkers for early identification of esophageal cancer, we analyzed the retinoic acid receptor-beta, p 53 protein and the proliferation marker Ki67 in surgical specimens of normal, mildly, and severely dysplastic and malignant esophageal tissues by in situ hybridization of RNA and immunohistochemistry. RAR-beta was expressed in 94.3%(33/35) of normal mucosae, 67.8%(19/28) of the mild, 58.1% (18/31) of the severe lesions and 53.2%(116/218) of tumor samples. RAR-beta mRNA was expressed in 62.7%(42/67), 55.1%(43/78) and 29.2%(7/24) of well, moderated and poorly differentiated SSCs. The p 53 and Ki67 proteins were 5.9%(2/34) of the normal mucosa. P53 and Ki67 stained positively in 10.7%(3/28) and 21.4% (6/28) of mild dysplasia, and 51.6%(16/31) and 58.1% (18/31) of severely dysplasia respectively. Samples from esophageal cancer showed no higher levers of p 53 and Ki67 expression than seen in severely dysplastic lesions. There was significant difference of RAR-beta p 53 and Ki67 expression between normal mucosa and dys...Continue Reading

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Citations

Mar 13, 2003·World Journal of Gastroenterology : WJG·Jun LinYa-Ping Wang
Sep 13, 2003·World Journal of Gastroenterology : WJG·Xiao-Feng YeWen-Jin Su
Sep 13, 2003·World Journal of Gastroenterology : WJG·Jian-Sheng WangJin-Guang Wu
Mar 13, 2003·World Journal of Gastroenterology : WJG·Hai-Tao WangZhi-Hua Liu
Nov 8, 2003·World Journal of Gastroenterology : WJG·Lian-Fu ZuoJiang-Hui Liu
Jun 12, 2003·World Journal of Gastroenterology : WJG·Li-Hong XuDong-Zhou Liu
Sep 15, 2005·International Journal of Cancer. Journal International Du Cancer·Ranju RalhanSuryanaryana V S Deo
Jun 20, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·D-C LinM-R Wang
Jul 31, 2012·Gastroenterology Research and Practice·Bernardo Silveira VolkweisMaria Isabel Edelweiss
Apr 9, 2008·Virchows Archiv : an International Journal of Pathology·Judith BooneFiebo J W Ten Kate
Jan 18, 2003·World Journal of Gastroenterology : WJG·Xi-Jiang ZhaoQing-Lai Feng

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