The abnormal response of polycystic ovarian disease patients to exogenous pulsatile gonadotropin-releasing hormone: characterization and management

The Journal of Clinical Endocrinology and Metabolism
M FilicoriA Pareschi

Abstract

Pulsatile GnRH administration for induction of ovulation is often ineffective in polycystic ovarian disease (PCOD) patients. To clarify and correct the endocrine mechanisms underlying this deranged response we gave pulsatile GnRH (5 micrograms, iv, every 60 min) to idiopathic hypogonadotropic hypogonadism (IHH) patients with primary amenorrhea for 19 cycles and to PCOD patients for 24 cycles before (pre-A) and for 25 cycles after (post-A) GnRH analog suppression. Compared to IHH, pre-A cycles were characterized by elevated LH, estradiol, and testosterone; reduced luteal phase progesterone; and low ovulatory (38%) and pregnancy rates (8%). Conversely, LH, estradiol, and follicular phase testosterone levels were lower in post-A than in pre-A cycles, while luteal phase progesterone was higher; the endocrine pattern of post-A cycles closely resembled the one of IHH cycles. The ovulatory and pregnancy rates of PCOD patients improved remarkably in post-A cycles (90% and 38%, respectively). Excessive body weight was associated with a lower incidence of ovulation in both pre-A (15%) and post-A cycles (75%). A worse endocrine pattern and a lower ovulatory rate (50%) were obtained when a second consecutive post-A cycle occurred without r...Continue Reading

Citations

Apr 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G Leyendecker, L Wildt
Jan 16, 1995·The American Journal of Medicine·M Gibson
Jul 1, 1997·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·L Hamberger, P O Janson
Jan 20, 1991·The New England Journal of Medicine·P M Conn, W F Crowley
Feb 18, 2006·Journal of Endocrinological Investigation·F P HohmannB C J M Fauser
Jun 1, 1997·Baillière's Clinical Obstetrics and Gynaecology·R B Barnes
Jan 11, 2000·Baillière's Clinical Obstetrics and Gynaecology·V LubinP Bouchard
Sep 1, 1990·Baillière's Clinical Obstetrics and Gynaecology·Z ShohamH S Jacobs
May 28, 1993·Annals of the New York Academy of Sciences·V MarkussisG Tolis
Mar 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Eveline W C M Van DamHanno Pijl
Jun 9, 2001·The Journal of Clinical Endocrinology and Metabolism·S GillJ E Hall
Sep 10, 2002·Obstetrical & Gynecological Survey·Elizabeth Anna Pritts
Nov 2, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Jia QiYun Sun

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