The Abnormality of Topological Asymmetry in Hemispheric Brain Anatomical Networks in Bipolar Disorder

Frontiers in Neuroscience
Bin WangDandan Li

Abstract

Convergent evidences have demonstrated a variety of regional abnormalities of asymmetry in bipolar disorder (BD). However, little is known about the alterations in hemispheric topological asymmetries. In this study, we used diffusion tensor imaging to construct the hemispheric brain anatomical network of 49 patients with BD and 61 matched normal controls. Graph theory was then applied to quantify topological properties of the hemispheric networks. Although small-world properties were preserved in the hemispheric networks of BD, the degrees of the asymmetry in global efficiency, characteristic path length, and small-world property were significantly decreased. More changes in topological properties of the right hemisphere than those of left hemisphere were found in patients compared with normal controls. Consistent with such changes, the nodal efficiency in patients with BD also showed less rightward asymmetry mainly in the frontal, occipital, parietal, and temporal lobes. In contrast to leftward asymmetry, significant rightward asymmetry was found in supplementary motor area of BD, and attributed to more deficits in nodal efficiency of the left hemisphere. Finally, these asymmetry score of nodal efficiency in the inferior parie...Continue Reading

References

Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
Jun 12, 1998·Nature·D J Watts, S H Strogatz
Jan 11, 2000·The British Journal of Psychiatry : the Journal of Mental Science·J R HighleyT J Crow
Oct 3, 2002·Annual Review of Psychology·Morton Ann Gernsbacher, Michael P Kaschak
Dec 10, 2002·Neuroscience and Biobehavioral Reviews·Florin DolcosRoberto Cabeza
Jan 4, 2003·Nature Reviews. Neuroscience·Arthur W Toga, Paul M Thompson
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
May 1, 2004·Bipolar Disorders·Michael P CaligiuriJames B Lohr
Jul 30, 2004·The New England Journal of Medicine·R H Belmaker
Jul 1, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·John L BeyerK Ranga R Krishnan
Feb 2, 2006·The American Journal of Psychiatry·Mani N PavuluriJohn A Sweeney
Nov 14, 2006·Biological Psychiatry·Mani N PavuluriJohn A Sweeney
Nov 25, 2006·Biological Psychiatry·Isabelle M RossoDeborah A Yurgelun-Todd
Feb 6, 2007·PLoS Computational Biology·Sophie Achard, Ed Bullmore
Feb 15, 2008·NeuroImage·Yasser Iturria-MedinaLester Melie-García
Mar 1, 2008·Journal of Psychopharmacology·Morgan HaldaneSophia Frangou
Sep 26, 2008·Biological Psychiatry·Andrew M McIntoshStephen M Lawrie
Dec 4, 2008·Journal of the American Academy of Child and Adolescent Psychiatry·Vivian KafantarisPhilip Szeszko
Feb 5, 2009·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Jul 25, 2009·Bipolar Disorders·Michèle WessaMarie-Laure Paillère-Martinot
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Jul 9, 2010·Biological Psychiatry·Lars M RimolIngrid Agartz
Feb 3, 2011·Journal of Psychiatry & Neuroscience : JPN·Sven HallerPanteleimon Giannakopoulos
Mar 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Feng BaiZhijun Zhang
Oct 6, 2012·Biological Psychiatry·Katie MahonPhilip R Szeszko
Feb 27, 2013·Frontiers in Human Neuroscience·Zaixu CuiGaolang Gong

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Citations

Jun 26, 2020·Bipolar Disorders·Victor ZengMatcheri Keshavan
Sep 22, 2019·Scientific Reports·Henrique M FernandesMorten L Kringelbach
Sep 29, 2020·Frontiers in Neuroinformatics·Dandan LiBin Wang
Aug 11, 2021·European Archives of Psychiatry and Clinical Neuroscience·Jasmina MalletUNKNOWN FACE-BD (FondaMental Academic Centers of Expertise for Bipolar Disorder) Group
Dec 18, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Jasmina MalletUNKNOWN FACE-SZ (FondaMental Academic Center of Expertise for Schizophrenia Group)

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Methods Mentioned

BETA
SMA

Software Mentioned

MATLAB
openfMRI
PANDA
GRETNA
BrainNet Viewer
Spearman
SPSS

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Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.