The ABO Histo-Blood Group and AKI in Critically Ill Patients with Trauma or Sepsis

Clinical Journal of the American Society of Nephrology : CJASN
John P ReillyMichael G S Shashaty

Abstract

ABO blood types are determined by antigen modifications on glycoproteins and glycolipids and associated with altered plasma levels of inflammatory and endothelial injury markers implicated in AKI pathogenesis. We sought to determine the association of ABO blood types with AKI risk in critically ill patients with trauma or sepsis. We conducted two prospective cohort studies at an urban, academic, level I trauma center and tertiary referral center; 497 patients with trauma admitted to the surgical intensive care unit between 2005 and 2010 with an injury severity score >15 and 759 patients with severe sepsis admitted to the medical intensive care unit between 2008 and 2013 were followed for 6 days for the development of incident AKI. AKI was defined by Acute Kidney Injury Network creatinine and dialysis criteria. Of 497 patients with trauma, 134 developed AKI (27%). In multivariable analysis, blood type A was associated with higher AKI risk relative to type O among patients of European descent (n=229; adjusted risk, 0.28 versus 0.14; risk difference, 0.14; 95% confidence interval, 0.03 to 0.24; P=0.02). Of 759 patients with sepsis, AKI developed in 326 (43%). Blood type A again conferred higher AKI risk relative to type O among pa...Continue Reading

References

Jan 1, 1988·The Journal of Trauma·I D Civil, C W Schwab
Dec 1, 1993·American Journal of Epidemiology·G Maldonado, S Greenland
Mar 4, 2000·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·V Ravn, E Dabelsteen
Apr 25, 2001·Biometrics·B I Graubard, E L Korn
Apr 12, 2003·Critical Care Medicine·Mitchell M LevyUNKNOWN SCCM/ESICM/ACCP/ATS/SIS
Apr 10, 2003·American Journal of Physiology. Renal Physiology·Timothy A SuttonBruce A Molitoris
Oct 3, 2003·Journal of Thrombosis and Haemostasis : JTH·C H MillerB Evatt
Apr 24, 2004·Transfusion·George GarrattyUNKNOWN Retrovirus Epidemiology Donor Study
Jul 16, 2004·Kidney International·John J Friedewald, Hamid Rabb
May 16, 2006·Critical Care : the Official Journal of the Critical Care Forum·Eric A J HosteJohn A Kellum
Mar 3, 2007·Critical Care : the Official Journal of the Critical Care Forum·Ravindra L MehtaUNKNOWN Acute Kidney Injury Network
Nov 2, 2007·Journal of Thrombosis and Haemostasis : JTH·O WuP Clark
Sep 6, 2008·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·José António LopesMateus Martins Prata
Sep 20, 2008·Nephron. Experimental Nephrology·Gilbert R KinseyMark D Okusa
Jan 30, 2009·Journal of the American Society of Nephrology : JASN·Asif A SharfuddinBruce A Molitoris
Sep 5, 2009·Injury·Takeshi TsukamotoHans-Christoph Pape
Sep 17, 2009·JAMA : the Journal of the American Medical Association·Ron WaldUNKNOWN University of Toronto Acute Kidney Injury Research Group
Oct 7, 2009·The Journal of Clinical Investigation·Kent DoiRobert A Star
Feb 20, 2010·Human Molecular Genetics·Maja BarbalicEmelia J Benjamin
Mar 24, 2010·Blood·David J Anstee
May 26, 2010·Clinical Journal of the American Society of Nephrology : CJASN·John W Pickering, Zoltán H Endre
May 14, 2011·Journal of the American Society of Nephrology : JASN·Abolfazl Zarjou, Anupam Agarwal
Nov 3, 2011·The Journal of Clinical Investigation·Joseph V Bonventre, Li Yang
Jul 17, 2012·JAMA : the Journal of the American Medical Association·V Marco RanieriArthur S Slutsky
Aug 17, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Meian HeLu Qi
Mar 1, 2014·Journal of Innate Immunity·Jan M HerterAlexander Zarbock
Apr 10, 2014·Annals of the American Thoracic Society·John P ReillyJason D Christie
Apr 12, 2014·Journal of the American Society of Nephrology : JASN·Morgan E GramsJosef Coresh
Jun 3, 2014·Critical Care : the Official Journal of the Critical Care Forum·Kuan-Liang LiuPao-Hsien Chu

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Citations

Feb 10, 2018·American Journal of Respiratory and Critical Care Medicine·Christian BimeJoe G N Garcia
Aug 2, 2018·American Journal of Respiratory and Critical Care Medicine·John P ReillyLorraine B Ware
Feb 7, 2019·Intensive Care Medicine·Signe SøvikSigrid Beitland
Aug 30, 2016·Ecological Processes·Jiquan ChenRaffaele Lafortezza
Apr 7, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Renqi YaoZhaofan Xia
May 3, 2018·Critical Care : the Official Journal of the Critical Care Forum·Wataru TakayamaYasuhiro Otomo
Apr 14, 2020·The Journal of Trauma and Acute Care Surgery·Charles R VasquezMichael G S Shashaty
Jun 30, 2019·Critical Care : the Official Journal of the Critical Care Forum·Michael G S ShashatyNilam S Mangalmurti
Nov 4, 2020·The Journal of Clinical Investigation·Alicia N Rizzo, Eric P Schmidt
Apr 21, 2021·Annals of Intensive Care·Theis S ItenovJens-Ulrik Jensen

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